Document Detail


Toll-like Receptor Levels and Caffeine Responsiveness in Rat Pups during Perinatal Period.
MedLine Citation:
PMID:  23313844     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Infants born prematurely are prone to bronchopulmonary dysplasia which is a devastating form of chronic lung disease that develops in very low birth weight infants. Toll-like receptors (TLRs) are pattern recognition receptors that initiate innate immune responses. We tested TLR2, 4, and 9 levels in the lungs of rat pups given caffeine at the first days of postnatal life. Twenty-four rat pups equally divided into three groups. The study group received caffeine immediately after birth for ten days. The levels of TLR9 were found significantly higher in study group than control groups. We conclude that the beneficial and anti-inflammatory effects of caffeine in the lungs of newborn rats may be due to increased TLR9 levels.
Authors:
Turan Tunc; Gokhan Aydemir; Abdulbaki Karaoglu; Ferhat Cekmez; Mustafa Kul; Secil Aydinoz; Oguzhan Babacan; Halil Yaman; Serdar Umit Sarici
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  Regulatory peptides     Volume:  -     ISSN:  1873-1686     ISO Abbreviation:  Regul. Pept.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Gulhane Military Medical Faculty, Department of Neonatology, Ankara/Turkey 06018.
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