| Toll-like receptors in sepsis: a tale still being told. | |
| | |
MedLine Citation:
|
PMID: 20509842 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Sepsis is a complex clinical situation responsible for thousands of deaths annually in intensive care units around the globe. Despite all our progress in providing medical care to critically ill patients, mortality of severe forms of sepsis did not decrease as expected. Part of this phenomenon is due to our defective understanding about the host immune response to aggression by a microorganism, including the part played by the pattern-recognition receptors (PRRs) in this process. PRRs are part of the innate immunity responsible for detecting non-self antigens and trigger the initial inflammatory response. The best known PRRs are the tol-like receptors (TLRs). In this article, we review some of our knowledge regarding the role of TLRs in sepsis, both in experimental models and in human patients. The improvement in our knowledge about the mediators and signaling pathways that control this immune response is crucial for the development of better markers of disease and new therapeutic targets, leading us to improve the way we treat septic patients. |
| | |
Authors:
|
Heraldo Possolo Souza; Thais Lima-Salgado; Luis Monteiro da Cruz Neto |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Endocrine, metabolic & immune disorders drug targets Volume: 10 ISSN: 2212-3873 ISO Abbreviation: Endocr Metab Immune Disord Drug Targets Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-09-23 Completed Date: 2011-01-04 Revised Date: 2012-04-19 |
Medline Journal Info:
|
Nlm Unique ID: 101269157 Medline TA: Endocr Metab Immune Disord Drug Targets Country: United Arab Emirates |
Other Details:
|
Languages: eng Pagination: 285-91 Citation Subset: IM |
Affiliation:
|
Laboratory of Medical Research, Division of Emergency Medicine, Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. Arnaldo, 455 sala 3189 01246-903 São Paulo, SP Brazil. heraldo@emercli.fm.usp.br |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Humans Sepsis / immunology*, metabolism* Signal Transduction / immunology* Toll-Like Receptors / immunology*, metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Toll-Like Receptors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Corticosteroids in sepsis: pathophysiological rationale and the selection of patients.
Next Document: Neurohypophyseal dysfunction during septic shock.