| Toll-like receptors at the maternal-fetal interface in normal pregnancy and pregnancy disorders. | |
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MedLine Citation:
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PMID: 20367625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Toll-like receptors (TLR) form the major family of pattern recognition receptors (PRR) that are involved in innate immunity. Innate immune responses against microorganisms at the maternal-fetal interface may have a significant impact on the success of pregnancy, as intrauterine infections have been shown to be strongly associated with certain disorders of pregnancy. At the maternal-fetal interface, TLRs are expressed not only in the immune cells but also in non-immune cells such as trophoblasts and decidual cells; moreover, their expression patterns vary according to the stage of pregnancy. Here, we will describe potential functions of TLRs in these cells, their recognition and response to microorganisms, and their involvement in the innate immunity. The impact of TLR-mediated innate immune response will be discussed via animal model studies, as well as clinical observations. |
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Authors:
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Kaori Koga; Gil Mor |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Review Date: 2010-03-29 |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 63 ISSN: 1600-0897 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-22 Completed Date: 2010-10-14 Revised Date: 2011-07-20 |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 587-600 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Tokyo School of Medicine, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Decidua* / immunology, metabolism Female Humans Maternal-Fetal Exchange / immunology* Mice Mice, Inbred BALB C Obstetric Labor, Premature / etiology, immunology Pre-Eclampsia / etiology, immunology Pregnancy Pregnancy Complications* / etiology, immunology Toll-Like Receptors / metabolism* Trophoblasts* / immunology, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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3N01 HD23342/HD/NICHD NIH HHS; P01 HD054713-03/HD/NICHD NIH HHS; P01HD054713/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Toll-Like Receptors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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