| Tolerogenic plasmacytoid DC. | |
| | |
MedLine Citation:
|
PMID: 20821731 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Plasmacytoid DC (pDC) are type-I IFN-producing cells known for their capacity to promote anti-viral innate and adaptive immune responses. Despite their potent anti-viral function, when compared with conventional DC, pDC exhibit poor immunostimulatory ability and their interaction with T cells often favors the generation of Treg. pDC are activated primarily in response to ssRNA and ssDNA through TLR7 and TLR9, respectively, but also through TLR-independent mechanisms. Non-lymphoid tissue pDC, such as those residing in the airways, gut, and liver, play a significant role in regulating mucosal immunity and are critical for the development of tolerance to inhaled or ingested antigens. Herein we discuss properties that define tolerogenic pDC and how their unique characteristics translate into an ability to regulate immunity and promote the development of tolerance. We cover the importance of pDC during intrathymic Treg development and the maintenance of peripheral tolerance, as well as their regulatory role in transplantation, autoimmunity, and cancer. We highlight recent findings regarding danger-associated molecular pattern and PAMP signaling in the regulation of pDC function, and how the ability of pDC to promote tolerance translates into the potential clinical applications of these cells as therapeutic targets to regulate immune reactivity. |
| | |
Authors:
|
Benjamin M Matta; Antonino Castellaneta; Angus W Thomson |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: European journal of immunology Volume: 40 ISSN: 1521-4141 ISO Abbreviation: Eur. J. Immunol. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-11-01 Completed Date: 2010-12-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: Germany |
Other Details:
|
Languages: eng Pagination: 2667-76 Citation Subset: IM |
Affiliation:
|
Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Dendritic Cells / immunology* Humans Immune Tolerance / immunology Immunity, Mucosal / immunology Mice T-Lymphocytes, Regulatory / immunology Toll-Like Receptors / immunology |
| Grant Support | |
ID/Acronym/Agency:
|
P01 AI81678/AI/NIAID NIH HHS; R01 AI60994/AI/NIAID NIH HHS; T32 AI74490/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Toll-Like Receptors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A dynamic immunological synapse mediates homeostatic TCR-dependent and -independent signaling.
Next Document: Proteomic analysis of germinating urediniospores of Phakopsora pachyrhizi, causal agent of Asian soy...