Document Detail

Tolerance to the trinitrophenol ligand in guinea pigs: studies on the role of the solvent used in feeding.
MedLine Citation:
PMID:  3943917     Owner:  NLM     Status:  MEDLINE    
Guinea pigs fed picryl sulfonic acid in aqueous solvents did not become unresponsive to contact sensitization with picryl chloride. In contrast, a substantial proportion of those fed picryl sulfonic acid, emulsified with triglyceride oil, were tolerant to subsequent immunization with picryl chloride. Feeding a related hapten (picryl chloride) in aqueous solvents was also considerably less effective in the induction of unresponsiveness to contact sensitization than feeding this hapten in vegetable oil. Animals fed picryl sulfonic acid in either aqueous or emulsified triglyceride solvents developed picryl-specific antibody after the initial feeding. However, those fed picryl chloride did not develop antibody and its role, if any, in the mechanism of unresponsiveness is unclear.
J R Pomeranz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International archives of allergy and applied immunology     Volume:  79     ISSN:  0020-5915     ISO Abbreviation:  Int. Arch. Allergy Appl. Immunol.     Publication Date:  1986  
Date Detail:
Created Date:  1986-02-28     Completed Date:  1986-02-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404561     Medline TA:  Int Arch Allergy Appl Immunol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  211-4     Citation Subset:  IM    
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MeSH Terms
Animal Feed
Dermatitis, Contact / immunology
Guinea Pigs
Haptens / immunology*
Immune Tolerance / drug effects*
Nitrobenzenes / immunology*
Picryl Chloride / immunology*
Trinitrobenzenes / immunology*
Grant Support
Reg. No./Substance:
0/Haptens; 0/Ligands; 0/Nitrobenzenes; 0/Solvents; 0/Trinitrobenzenes; 88-88-0/Picryl Chloride

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