| Tolerance to the trinitrophenol ligand in guinea pigs: studies on the role of the solvent used in feeding. | |
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MedLine Citation:
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PMID: 3943917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Guinea pigs fed picryl sulfonic acid in aqueous solvents did not become unresponsive to contact sensitization with picryl chloride. In contrast, a substantial proportion of those fed picryl sulfonic acid, emulsified with triglyceride oil, were tolerant to subsequent immunization with picryl chloride. Feeding a related hapten (picryl chloride) in aqueous solvents was also considerably less effective in the induction of unresponsiveness to contact sensitization than feeding this hapten in vegetable oil. Animals fed picryl sulfonic acid in either aqueous or emulsified triglyceride solvents developed picryl-specific antibody after the initial feeding. However, those fed picryl chloride did not develop antibody and its role, if any, in the mechanism of unresponsiveness is unclear. |
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Authors:
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J R Pomeranz |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: International archives of allergy and applied immunology Volume: 79 ISSN: 0020-5915 ISO Abbreviation: Int. Arch. Allergy Appl. Immunol. Publication Date: 1986 |
Date Detail:
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Created Date: 1986-02-28 Completed Date: 1986-02-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404561 Medline TA: Int Arch Allergy Appl Immunol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 211-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed Animals Dermatitis, Contact / immunology Female Guinea Pigs Haptens / immunology* Immune Tolerance / drug effects* Ligands Male Nitrobenzenes / immunology* Picryl Chloride / immunology* Solvents Trinitrobenzenes / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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5 TO1-AMO-5608/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Haptens; 0/Ligands; 0/Nitrobenzenes; 0/Solvents; 0/Trinitrobenzenes; 88-88-0/Picryl Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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