| Tolerance to morphine-produced discriminative stimuli and analgesia. | |
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MedLine Citation:
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PMID: 412218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Male hooded rats were trained in Skinner boxes to press one lever after a morphine injection (10 mg/kg) and another lever after a saline injection (1 ml/kg) on an FR 10 schedule of food reinforcement. After the drug discrimination was well established, the rats were tested for stimulus generalization at different doses of morphine, followed by assessment of tail withdrawal latency as a measure of analgesia. Subjects were then administered increasing doses of morphine sulphate to induce an increased level of tolerance. New dose-response curves indicated that tolerance developed to the morphine-induced discriminative stimulus, and to the analgesic action of morphine, but doses of morphine that failed to cause detectable analgesia still produced a pronounced discriminative stimulus. |
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Authors:
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S Miksic; H Lal |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Psychopharmacology Volume: 54 ISSN: 0033-3158 ISO Abbreviation: Psychopharmacology (Berl.) Publication Date: 1977 Oct |
Date Detail:
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Created Date: 1978-01-27 Completed Date: 1978-01-27 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7608025 Medline TA: Psychopharmacology (Berl) Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 217-21 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesia* Animals Discrimination Learning / drug effects Dose-Response Relationship, Drug Drug Tolerance Male Morphine / administration & dosage*, pharmacology Rats Time Factors |
| Chemical | |
Reg. No./Substance:
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57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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