| Tolerance to heat of rats treated by beta-blocker. Role of submaxillary salivary glands. | |
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MedLine Citation:
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PMID: 2421666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effect of beta-adrenoceptor blockade on the changes in rectal temperature (RT), heat production (HP) and noradrenaline (NA) concentration in the submaxillary salivary glands (SMSG) of rats exposed to heat (45 degrees C) was studied. Propranolol (P) (15 mg/kg i.p.) decreased the tolerance to heat. The survival time of propranolol-treated (PT) rats was 30 min shorter. The temperature curve of control rats exposed to heat can be divided into three phases: a rapid rise in RT; a plateau (TP) and a prelethal increase. In PT animals, under identical conditions, TP disappears and RT further rises accelerating death. In the initial phase of heat exposure, HP was markedly decreased to the same extent in both experimental groups; but after 20 min HP increases in PT rats. The content of NA from SMSG both in the initial phase and in the TP phase is modified in PT rats. |
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Authors:
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V Davidović; V Ratković; S Tatić |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives internationales de physiologie et de biochimie Volume: 93 ISSN: 0003-9799 ISO Abbreviation: Arch. Int. Physiol. Biochim. Publication Date: 1985 Nov |
Date Detail:
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Created Date: 1986-05-06 Completed Date: 1986-05-06 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0405355 Medline TA: Arch Int Physiol Biochim Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 291-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology* Animals Body Temperature Regulation / drug effects* Hot Temperature* Male Norepinephrine / blood, metabolism Oxygen Consumption / drug effects Propranolol / pharmacology Rats Rats, Inbred Strains Submandibular Gland / metabolism, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 51-41-2/Norepinephrine; 525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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