Document Detail


Tolerance and efficacy of interferon-alpha in hemodialysis patients in Tripoli.
MedLine Citation:
PMID:  16970253     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A prospective non-randomized study was conducted at the Department of Infectious Diseases at Tripoli Medical Center. We evaluated the tolerance and efficacy of interferon-alpha (IFN) monotherapy in our hemodialysis (HD) patients with chronic hepatitis C virus (HCV) infection. Patients with evidence of active viral infection i.e. positive polymerase chain reaction (PCR) results and who were potential transplant candidates were included in the study. They received three million units of IFN-alpha, administered subcutaneously, three times a week for 12 months. The treatment was discontinued in 12 out of the 35 treated patients (i.e drop out rate 34.2%). Among the 23 patients who completed the treatment course, 14 (60.8%) became PCR negative, and by the end of eighteen months, nine of the patients maintained PCR negativity (39%). Thus, a sustained virological response was observed in nine (25.7%) of the 35 enrolled patients. Our study suggests that the efficacy of IFN-alpha in our patients was less than anticipated and the tolerance to the drug was poor. However, studies involving larger numbers of patients are required to optimize the treatment protocol.
Authors:
Mahdia Buargub; Suheir El Huni; Mohd Tagdi
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia     Volume:  17     ISSN:  1319-2442     ISO Abbreviation:  Saudi J Kidney Dis Transpl     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-14     Completed Date:  2006-10-12     Revised Date:  2006-11-21    
Medline Journal Info:
Nlm Unique ID:  9436968     Medline TA:  Saudi J Kidney Dis Transpl     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  338-43     Citation Subset:  IM    
Affiliation:
Tripoli Central Hospital, Tripoli, Libya. mahdiabuargub@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antiviral Agents / administration & dosage,  therapeutic use*
Drug Tolerance*
Female
Follow-Up Studies
Hepacivirus / genetics
Hepatitis C, Chronic / complications,  drug therapy*,  virology
Humans
Injections, Subcutaneous
Interferon-alpha / administration & dosage,  therapeutic use*
Kidney Failure, Chronic / complications,  therapy
Male
Middle Aged
Polymerase Chain Reaction
Prospective Studies
RNA, Viral / genetics
Renal Dialysis*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Interferon-alpha; 0/RNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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