| Tolerance and efficacy of an air-filled balloon in non-morbidly obese patients: results of a prospective multicenter study. | |
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MedLine Citation:
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PMID: 17879576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Intragastric balloons have been proposed to induce body weight loss in obese subjects. Most studies were performed using liquid-filled balloons. Air-filled balloons may increase digestive tolerance. Our goal was to study the tolerance and efficacy of a new air-filled intragastric balloon in nonmorbidly obese patients. METHODS: 32 patients were included, with a mean BMI of 35.0 (range 30.1-40.0). The balloon was inserted under general anaesthesia, inflated with 800 ml of air, and removed 4 months later. Tolerance and body weight were monitored until 12 months after removal. Ghrelin levels were measured before balloon insertion, 1 and 4 weeks after, and before removal. RESULTS: Weight loss was significant at 1, 2 and 4 months after balloon insertion (6, 7 and 10 kg, respectively, P<0.001). Early removal of the balloon occurred in 3 cases. 28 patients were contacted 12 months after balloon removal: 2 had undergone gastric banding; among the 26 remaining, the mean weight loss was 7 kg. 9 patients (30%) remained with a weight loss >10%, and satisfaction with the method was 87% for these 9 patients, and 22% for the other patients who had weight loss <10% (P<0.04). Fasting plasma ghrelin levels increased at week 1 and 4 after balloon insertion, and decreased at week 16 (P<0.001). CONCLUSIONS. The air-filled intragastric balloon was safe. Its effect on weight loss appeared equivalent to other balloons. 12 months after balloon removal, 30% of the patients maintained a weight loss >10%. |
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Authors:
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François Mion; Rodica Gincul; Sabine Roman; Sylvain Beorchia; Frank Hedelius; Nicolas Claudel; Roger-Michel Bory; Etienne Malvoisin; Frédérique Trepo; Bertrand Napoleon |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study |
Journal Detail:
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Title: Obesity surgery Volume: 17 ISSN: 0960-8923 ISO Abbreviation: Obes Surg Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-09-20 Completed Date: 2007-11-08 Revised Date: 2007-12-05 |
Medline Journal Info:
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Nlm Unique ID: 9106714 Medline TA: Obes Surg Country: England |
Other Details:
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Languages: eng Pagination: 764-9 Citation Subset: IM |
Affiliation:
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Hospices Civils de Lyon, Fédération des Spécialités Digestives, Hôpital E. Herriot, Lyon, France. francois.mion@chu-lyon.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Air Equipment Design Female Follow-Up Studies Gastric Balloon* Humans Male Middle Aged Obesity / therapy* Prospective Studies Treatment Outcome Weight Loss |
| Comments/Corrections | |
Erratum In:
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Obes Surg. 2007 Jul;17(7):996 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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