| Tolerability and efficacy of a low-volume enteral supplement containing key nutrients in the critically ill. | |
| | |
MedLine Citation:
|
PMID: 21621886 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND & AIMS: To compare early supplementation with antioxidants and glutamine using a low-volume enteral supplement containing key nutrients to an energy adjusted standard elementary diet and to investigate its effect on clinical efficacy and tolerability in critically ill patients with sepsis/SIRS. The primary endpoints were length of stay in the ICU and sufficient enteral feed. METHODS: This was a randomized, prospective, single-blind, controlled study in 58 critically ill patients (56.9% male, mean age 46.7 years, mean APACHE II score 21.6). They received either a low-volume enteral supplement containing key nutrients or a diluted standard nutrition solution. After 10 or 14 days inflammatory parameters, catecholamine need, and maximal enteral delivery were determined. RESULTS: Patients receiving a low-volume enteral supplement containing key nutrients did not reach sufficient enteral feed more often than controls (76 vs. 62%, respectively, p = 0.17). The difference in vitamin E and selenium uptake was higher in the treatment group than controls (12.4 vs. 3.7 and 54.7 vs. 16.3, respectively, p ≤ 0.011). Parameters such as fever, antibiotic treatment, artificial ventilation, and death were comparable. This was also true for days of ICU or hospital stay (33 ± 23 and 49 ± 34 days, respectively). CONCLUSIONS: The low-volume enteral supplement containing key nutrients was well tolerated and led to a better vitamin E and selenium supply. However, it did not affect length of ICU or hospital stay. Further studies are necessary to determine which disease-specific subgroups may benefit from this supplementation or which group may be harmed. |
| | |
Authors:
|
Andrea Schneider; Andrea Markowski; Michael Momma; Claudia Seipt; Birgit Luettig; Johannes Hadem; Michaela Wilhelmi; Michael P Manns; Jochen Wedemeyer |
Related Documents
:
|
22055006 - Thoracic paravertebral block for video-assisted thoracoscopic surgery: single injection... 9263286 - Thiazide-induced hyponatremia in the postoperative total joint replacement patient. 21684606 - Sustained benefits from ranibizumab for macular edema following branch retinal vein occ... 2918006 - Capitellocondylar total elbow replacement. a long-term follow-up study. 23483496 - Comparison of intrastromal corneal ring segment implantation only and in combination wi... 19436116 - Predicting the efficacy of antiarrhythmic agents for interrupting persistent atrial fib... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-27 |
Journal Detail:
|
Title: Clinical nutrition (Edinburgh, Scotland) Volume: - ISSN: 1532-1983 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8309603 Medline TA: Clin Nutr Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. |
Affiliation:
|
Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Molecular modelling studies on Arylthioindoles as potent inhibitors of tubulin polymerization.
Next Document: What you eat is what you are - A role for polyunsaturated fatty acids in neuroinflammation induced d...