| Tolerability and safety of biological therapies for psoriasis in daily clinical practice: a study of 103 Italian patients. | |
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MedLine Citation:
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PMID: 21088813 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies comparing the safety and tolerability of biological therapies for psoriasis in the long-term and in daily clinical practice are lacking. Most published studies are of selected patients with short-term (3-6 months) follow-up. We performed a retrospective cohort study of 103 patients in order to describe the frequency and the clinical features of adverse events, and to evaluate and compare the tolerability and safety of efalizumab, etanercept, infliximab, and adalimumab in clinical practice. A total of 136 courses of biological therapies were administered, with a mean duration of 16 months/patient; 55 patients received efalizumab, 45 etanercept, 33 infliximab, and 3 adalimumab. Infliximab had an incidence rate ratio of suspension due to severe adverse events 5.9 times (95% confidence interval (95% CI) 1.9-18, p < 0.001) higher than etanercept and 9.8 times (95% CI 3.2-30.1, p < 0.001) higher than efalizumab. Safety profiles for efalizumab and etanercept were more favourable than for infliximab. Concerning tolerability, we found that more patients responded to infliximab, but long-term tolerability was higher for both efalizumab and etanercept due to the better safety profile and a higher compliance to therapy. |
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Authors:
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Alexandra M G Brunasso; Matteo Puntoni; Camilla Salvini; Chiara Delfino; Pero Curcic; Andra Gulia; Cesare Massone |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta dermato-venereologica Volume: 91 ISSN: 1651-2057 ISO Abbreviation: Acta Derm. Venereol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-25 Completed Date: 2011-04-20 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 0370310 Medline TA: Acta Derm Venereol Country: Sweden |
Other Details:
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Languages: eng Pagination: 44-9 Citation Subset: IM |
Affiliation:
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Department of Environmental Dermatology, Medical University of Graz, Austria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Anti-Inflammatory Agents / adverse effects, therapeutic use* Antibodies, Monoclonal / adverse effects, therapeutic use* Antibodies, Monoclonal, Humanized Dermatologic Agents / adverse effects, therapeutic use* Female Humans Immunoglobulin G / adverse effects, therapeutic use Male Middle Aged Psoriasis / drug therapy* Receptors, Tumor Necrosis Factor / therapeutic use Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/Dermatologic Agents; 0/Immunoglobulin G; 0/Receptors, Tumor Necrosis Factor; 0/adalimumab; 0/efalizumab; 0/infliximab; 185243-69-0/TNFR-Fc fusion protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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