Document Detail


Tolerability of curcumin in pediatric inflammatory bowel disease: a forced-dose titration study.
MedLine Citation:
PMID:  23059643     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation in the absence of a recognized etiology. The primary therapies are medications that possess anti-inflammatory or immunosuppressive effects. Given the high use of complementary alternative medicines in pediatric IBD, a prospective tolerability study of curcumin, an herbal therapy with known anti-inflammatory effects, was conducted to assess possible dosage in children with IBD.
METHODS: Prospectively, patients with Crohn disease or ulcerative colitis in remission or with mild disease (Pediatric Crohn's Disease Activity Index [PCDAI] <30 or Pediatric Ulcerative Colitis Activity Index [PUCAI] score <34) were enrolled in a tolerability study. All patients received curcumin in addition to their standard therapy. Patients initially received 500 mg twice per day for 3 weeks. Using the forced-dose titration design, doses were increased up to 1 g twice per day at week 3 for a total of 3 weeks and then titrated again to 2 g twice per day at week 6 for 3 weeks. Validated measures of disease activity, using the PUCAI and PCDAI, and the Monitoring of Side Effect System score were obtained at weeks 3, 6, and 9.
RESULTS: All patients tolerated curcumin well, with the only symptom that was consistently reported during all 3 visits being an increase in gassiness, which occurred in only 2 patients. Three patients saw improvement in PUCAI/PCDAI score.
CONCLUSIONS: This pilot study suggests that curcumin may be used as an adjunctive therapy for individuals seeking a combination of conventional medicine and alternative medicine.
Authors:
David L Suskind; Ghassan Wahbeh; Tyler Burpee; Morty Cohen; Dennis Christie; Wendy Weber
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  56     ISSN:  1536-4801     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-08-27     Revised Date:  2014-05-30    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  277-9     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00889161
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  adverse effects*,  therapeutic use
Child
Colitis, Ulcerative / diet therapy*,  drug therapy,  immunology,  physiopathology
Combined Modality Therapy / adverse effects
Crohn Disease / diet therapy*,  drug therapy,  immunology,  physiopathology
Curcumin / administration & dosage,  adverse effects*,  therapeutic use
Dietary Supplements / adverse effects*,  analysis
Female
Flatulence / etiology
Humans
Inflammatory Bowel Diseases / diet therapy,  drug therapy,  immunology,  physiopathology
Male
Medicine, Ayurvedic
Mesalamine / therapeutic use
Pilot Projects
Remission Induction
Severity of Illness Index
Tumor Necrosis Factor-alpha / antagonists & inhibitors
Grant Support
ID/Acronym/Agency:
KL2 RR025015/RR/NCRR NIH HHS; KL2 RR025015/RR/NCRR NIH HHS; TL1 RR025016/RR/NCRR NIH HHS; TL1 RR025016/RR/NCRR NIH HHS; UL1 RR025014/RR/NCRR NIH HHS; UL1 RR025014/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Tumor Necrosis Factor-alpha; 4Q81I59GXC/Mesalamine; IT942ZTH98/Curcumin
Comments/Corrections

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