Document Detail


Today's and yesterday's of pathophysiology: Biochemistry of metabolic syndrome and animal models.
MedLine Citation:
PMID:  24290591     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
During the past 20 y, there has been much interest in sugars and especially fructose in relation to human health. Over the past decade, considerable scientific debate and controversy have arisen about the potential health effects of sucrose, high-fructose corn syrup (HFCS), and fructose itself. HFCS increasingly has been used as a sweetener in thousands of food products and soft drinks, leading to the development of obesity, diabetes, dyslipidemia, and metabolic syndrome (MetS) in both rodents and humans, which is associated with an increase in body weight. There is a need for detailed research on the mechanism underlying MetS that could lead to a remedy. This review will first systematically present a definition of MetS, its history, prevalence, and comparative diagnostic criteria. We will then consider fructose and its effects on human health, the diet-induced obesity model (various fat contents), the hypercholesterolemic model, the diabetes model, the hypertensive model, the MetS or insulin resistance model, and biomarkers related to MetS, in light of contemporary data using multiple databases (PubMed, MEDLINE, and OVID).
Authors:
Suleyman Aydin; Aziz Aksoy; Suna Aydin; Mehmet Kalayci; Musa Yilmaz; Tuncay Kuloglu; Cihan Citil; Zekiye Catak
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  30     ISSN:  1873-1244     ISO Abbreviation:  Nutrition     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2013-12-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
Affiliation:
Department of Medical Biochemistry and Clinical Biochemistry (Firat Hormones Research Group), Medical Faculty, Firat University, Elazig, Turkey. Electronic address: saydin1@firat.edu.tr.
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