Document Detail

Tocopherol isomer pattern in serum and stool of human following consumption of black currant seed press residue administered in whole grain bread.
MedLine Citation:
PMID:  19523725     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: Serum gamma-tocopherol is thought to be associated with human health. The dietary influence of tocopherol and fibre-rich black currant seed press residue on serum and stool tocopherol concentration was investigated in a controlled human intervention study. METHODS: Thirty-six women consumed bread enriched with black currant press residue (4 weeks). The resultant faecal and serum tocopherol concentrations were compared with those after a period consuming control bread without press residue and a normal baseline diet. Fibre intake and excretion, antioxidant capacity (TEAC), and vitamin C concentrations in serum and urine were also determined. Samples were obtained with a 5-day standardised diet at the end of each period. RESULTS: The press residue bread lead to significantly increased beta-, gamma-, delta- and total tocopherol intake, serum alpha-, beta-, gamma- and total tocopherol concentration (with and without lipid adjustment), fibre intake and urinary vitamin C concentration compared to control bread (P<0.05). Faecal excretion of total tocopherols and fibre increased compared to baseline (P<0.05). CONCLUSIONS: Fibre intake and excretion influence total tocopherol concentration in lipid-adjusted serum and in stool. The outstandingly high increase of serum gamma-tocopherol concentration through seed press residue consumption could be due to a presumed interruption of the enzymatic tocopherol degradation mechanism by bread constituents.
Dorit Helbig; Andreas Wagner; Rainer Schubert; Gerhard Jahreis
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-11
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  28     ISSN:  1532-1983     ISO Abbreviation:  Clin Nutr     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-16     Completed Date:  2010-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  662-7     Citation Subset:  IM    
Friedrich Schiller University of Jena, Department of Nutritional Physiology, Dornburger Strasse 24-29, D-07743 Jena, Germany.
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MeSH Terms
Antioxidants / analysis
Ascorbic Acid / blood,  urine
Bread* / analysis
Dietary Fiber / administration & dosage,  metabolism
Feces / chemistry*
Ribes / chemistry*
Seeds / chemistry*
Tocopherols / analysis,  blood*
Waste Products / analysis*
Young Adult
gamma-Tocopherol / analysis,  blood
Reg. No./Substance:
0/Antioxidants; 0/Waste Products; 0/gamma-Tocopherol; 1406-66-2/Tocopherols; 50-81-7/Ascorbic Acid

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