| α-Tocopherol binding to human serum albumin. | |
| | |
MedLine Citation:
|
PMID: 23355326 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Given the ability of human serum albumin (HSA) to bind hydrophobic ligands, the binding mode of α-tocopherol, the most representative member of the vitamin E family, is reported. α-Tocopherol binds to HSA with K $_{\rm d}^0$ = (7.0 ± 3.0) × 10(-6) M (pH 7.2, 25.0°C). Competitive and allosteric modulation of α-tocopherol binding to full-length and truncated (Asp1-Glu382) HSA by endogenous and exogenous ligands suggests that it accommodates preferentially in the FA3-FA4 site. As HSA is taken up into cells, colocalizes with the α-tocopherol transfer protein, and contributes to ligand secretion via ABCA1, it might participate in the distribution of α-tocopherol between plasma, cells, and tissues. © 2013 BioFactors, 2013. |
| | |
Authors:
|
Gabriella Fanali; Mauro Fasano; Paolo Ascenzi; Jean-Marc Zingg; Angelo Azzi |
Related Documents
:
|
2539466 - Coupling of hepatic prostaglandin receptors to adenylate cyclase through a pertussis to... 23302896 - Role of interactions between autographa californica multiple nucleopolyhedrovirus proca... 15922596 - Novel phomactin analogues as paf receptor ligands. 23586726 - Interaction of synthetic peptide octarphin with human blood lymphocytes. 10479286 - Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyr... 16014956 - Soluble mimetics of human immunodeficiency virus type 1 viral spikes produced by replac... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-28 |
Journal Detail:
|
Title: BioFactors (Oxford, England) Volume: - ISSN: 1872-8081 ISO Abbreviation: Biofactors Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8807441 Medline TA: Biofactors Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2013 International Union of Biochemistry and Molecular Biology, Inc. |
Affiliation:
|
Division of Biomedical Sciences, Department of Theoretical and Applied Sciences, Center of Neuroscience, University of Insubria, Busto Arsizio (VA), Italy. gabriella.fanali@uninsubria.it. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical Psychologists' Experiences of Reflective Staff Groups in Inpatient Psychiatric Settings: A ...
Next Document: Chemistry in Sweden-A Midsummer Night's Dream?