| Tocolytic effectiveness of nifedipine versus ritodrine and follow-up of newborns: a randomised controlled trial. | |
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MedLine Citation:
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PMID: 18307075 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Several studies have demonstrated the superior tocolytic effectiveness of nifedipine over ritodrine. Only 1 trial conducted a long-term follow-up of newborns and found no difference in psychosocial and motor functioning. In a randomised, multicentre trial, we compared the tocolytic effectiveness of nifedipine and ritodrine and included a long-term follow-up of the newborns after 2 years of age. METHODS: Patients with imminent preterm labour were randomised and received either nifedipine or ritodrine. Side-effects, tocolytic effectiveness and neonatal outcome were studied. Development of the children was studied after the age of 2 years by a parental questionnaire. RESULTS: Ninety-three patients were included. Birth was postponed for an average of 4.3 weeks in the ritodrine group and 5.0 weeks in the nifedipine group (p=0.4). Patients who received ritodrine experienced significantly more side-effects compared to patients who received nifedipine (29 versus 4%, p<0.05). No significant differences were found in either group for average birth weight, Apgar scores after 1 min, neonatal intensive care unit (NICU) admission and neonatal complications. Parental questionnaires after 2 years had a response rate of 70%. Two-thirds of the children had developed normally in both groups. In both groups, only a few children were severely retarded (n=4). No significant differences in development were found between the 2 groups. CONCLUSIONS: Both nifedipine and ritodrine proved effective tocolytic drugs, however ritodrine caused significantly more maternal side-effects. Neonatal outcome and long-term development after 2 years of age were not significantly different. We favour nifedipine over ritodrine as a tocolytic drug. |
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Authors:
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M Van De Water; E Timmerman-Van Kessel; M J De Kleine; S G Oei |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: 87 ISSN: 1600-0412 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 2008 |
Date Detail:
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Created Date: 2008-02-29 Completed Date: 2008-03-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 340-5 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, Máxima Medical Centre, The Netherlands. m.vandewater@alumni.unimaas.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Agonists
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adverse effects,
therapeutic use Adult Birth Weight Calcium Channel Blockers / adverse effects, therapeutic use Child, Preschool Female Follow-Up Studies Gestational Age Humans Infant, Newborn Nifedipine / adverse effects, therapeutic use* Obstetric Labor, Premature / prevention & control* Pregnancy Questionnaires Ritodrine / adverse effects, therapeutic use* Tocolysis / adverse effects, methods* Tocolytic Agents / adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 0/Calcium Channel Blockers; 0/Tocolytic Agents; 21829-25-4/Nifedipine; 26652-09-5/Ritodrine |
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