Document Detail


Tocolytic effect of the cyclooxygenase-2 inhibitor, meloxicam: studies on uterine contractions in the rat.
MedLine Citation:
PMID:  9680081     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to assess the tocolytic activity of meloxicam, a novel cyclooxygenase-2 inhibitor, in a comparative study with the non-steroidal anti-inflammatory drug, indomethacin. The in-vitro tocolytic effect of meloxicam and indomethacin (10(-9)-10(-5)M) was evaluated on spontaneously-contracting uterine strips from non-pregnant rats and from rats at various stages of pregnancy. The rhythmic motility of the strips was reproducibly maintained over several hours. The effect of drugs was evaluated from the extent of inhibition of the frequency and amplitude of contractions. Both indomethacin and meloxicam induced dose-dependent inhibitory effects, with meloxicam being slightly more potent in all groups studied, particularly in early pregnancy. These results suggest that meloxicam, which has fewer side-effects than cyclooxygenase-1 inhibitors, could be a potentially useful tocolytic agent in the treatment of premature labour.
Authors:
M H Yousif; O Thulesius
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  50     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-09-21     Completed Date:  1998-09-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  681-5     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Cyclooxygenase Inhibitors / pharmacology*
Dose-Response Relationship, Drug
Female
Indomethacin / pharmacology*
Pregnancy
Rats
Rats, Sprague-Dawley
Thiazines / pharmacology*
Thiazoles / pharmacology*
Tocolytic Agents / pharmacology*
Uterine Contraction / drug effects*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cyclooxygenase Inhibitors; 0/Thiazines; 0/Thiazoles; 0/Tocolytic Agents; 53-86-1/Indomethacin; 71125-38-7/meloxicam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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