| Tocolysis with nifedipine or beta-adrenergic agonists: a meta-analysis. | |
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MedLine Citation:
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PMID: 11336775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To clarify the relative efficacy of nifedipine and beta-agonists for tocolysis. DATA SOURCES: The literature was searched in the following databases: MEDLINE 1965-1998, Embase 1988-1998, Current Contents 1997-1998, and the Cochrane Database for 1998. We also sought unpublished trials and abstracts submitted to major international congresses. Search terms were: "tocolysis," "nifedipine," "calcium channel blocker," "ritodrine," "terbutaline," and "salbutamol."Methods of Study Selection: Randomized controlled trials comparing tocolysis with nifedipine and beta-adrenergic agonists during preterm labor were reviewed. In cases with postrandomization exclusions, authors were contacted to obtain intent-to-treat results and to avoid analytical bias. We identified 11 published and two unpublished randomized trials. TABULATION, INTEGRATION, AND RESULTS: Data were extracted by two reviewers and analyzed by a blinded biostatistician with RevMan 3.1 software from the Cochrane Collaboration. We analyzed nine relevant randomized controlled trials that included 679 patients. Meta-analysis showed that nifedipine was more effective than the beta-agonists in delaying delivery at least 48 hours [odds ratio (OR) 1.52, 95% confidence interval (CI) 1.03, 2.24], or over 34 weeks (OR 1.87, 95% CI 1.11, 3.15). The agents did not differ as to the incidence of deliveries after 37 weeks (OR 1.29, 95% CI 0.85, 1.96) or the neonatal mortality rate (OR 1.51, 95% CI 0.63, 3.65). Treatment with nifedipine was interrupted significantly less often because of side effects (OR 0.12, 95% CI 0.05, 0.29) and led to better neonatal outcomes (fewer infants with respiratory distress syndrome: OR 0.57, 95% CI 0.37, 0.89) or transferred to neonatal intensive care units (OR 0.65, 95% CI 0.43, 0.97). CONCLUSION: With respect to neonatal outcome, nifedipine appears to be more effective than beta-agonists for tocolysis and should be considered for use as a first-line tocolytic agent. |
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Authors:
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V Tsatsaris; D Papatsonis; F Goffinet; G Dekker; B Carbonne |
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Publication Detail:
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Type: Journal Article; Meta-Analysis |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 97 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-05-04 Completed Date: 2001-05-24 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 840-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Hôpital Saint-Antoine, 184 rue du Faubourg Saint Antoine, 75012 Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Agonists
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therapeutic use* Female Humans Nifedipine / therapeutic use* Obstetric Labor, Premature* Pregnancy Randomized Controlled Trials as Topic Tocolysis* Tocolytic Agents / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 0/Tocolytic Agents; 21829-25-4/Nifedipine |
| Comments/Corrections | |
Comment In:
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Obstet Gynecol. 2002 Mar;99(3):518-9; author reply 519-20
[PMID:
11864692
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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