| Tocilizumab in Refractory Adult-Onset Still's Disease with Aseptic Meningitis-Efficacy of Interleukin-6 Blockade and Review of the Literature. | |
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MedLine Citation:
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PMID: 20621335 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Adult-onset Still's disease is a multisystem inflammatory disorder of unknown etiology characterized by typical spiking fever, evanescent rash, arthralgia, and leucocytosis. Neurologic manifestations are infrequent, seen in 7 to 12% of cases. We present the case of a young male admitted with aseptic meningitis that satisfied the diagnostic criteria of Adult-onset Still's disease. Refractoriness to therapy with corticosteroids and cyclosporine A led to the use of humanized monoclonal anti-interleukin-6 receptor antibody "tocilizumab" with dramatic response. The case is reported for the rarity of presentation and the need to consider the diagnosis in related clinical scenarios. Also, current literature on the use of tocilizumab in intractable disease is reviewed. |
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Authors:
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Girish R Sabnis; Yojana A Gokhale; Uday P Kulkarni |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Seminars in arthritis and rheumatism Volume: 40 ISSN: 1532-866X ISO Abbreviation: Semin. Arthritis Rheum. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1306053 Medline TA: Semin Arthritis Rheum Country: United States |
Other Details:
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Languages: eng Pagination: 365-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Resident, Rheumatology Services, Department of Medicine, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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