| Tocilizumab dramatically ameliorated life-threatening diarrhea due to secondary amyloidosis associated with rheumatoid arthritis. | |
| | |
MedLine Citation:
|
PMID: 19437089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Severe diarrhea improved dramatically with administration of the humanized anti-interleukin-6 receptor antibody tocilizumab (TCZ) in a patient with secondary reactive amyloidosis, which was associated with rheumatoid arthritis (RA). A 53-year-old woman with RA went into hypovolemic shock because of severe watery diarrhea associated with gastrointestinal amyloidosis. The high-dose prednisolone therapy and glucocorticoid pulse therapy did not improve her intractable diarrhea. After TCZ administration, the life-threatening diarrhea lessened in about 6 h, and her vital signs became stable the next day. Perforation of the small intestine, however, occurred 2 days after TCZ administration. Whether TCZ could have been involved in the perforation in such a short time is unknown. Surgery was successful, and the patient recovered. TCZ may work immediately in diarrhea associated with secondary amyloidosis. |
| | |
Authors:
|
Hiroe Sato; Takehito Sakai; Toshiaki Sugaya; Yasuhiro Otaki; Kana Aoki; Katsushi Ishii; Hidehiro Horizono; Hiroshi Otani; Asami Abe; Noboru Yamada; Hajime Ishikawa; Kiyoshi Nakazono; Akira Murasawa; Fumitake Gejyo |
Related Documents
:
|
16622719 - Twenty-four-week follow-up examination of a leukocytapheresis therapy in rheumatoid art... 10681719 - Prolonged response to cyclosporin-a in hypoplastic refractory anemia and correlation wi... 20680379 - Use of infliximab in a patient with pyoderma gangrenosum and rheumatoid arthritis. 10529149 - Two cases of methotrexate induced lymphomas in rheumatoid arthritis: an association wit... 18484659 - Protein oxidation markers in the serum and synovial fluid of psoriatic arthritis patients. 20063189 - Disseminated cutaneous and visceral kaposi sarcoma in a woman with rheumatoid arthritis... 19479879 - Elevated serum interferon-alpha activity in juvenile dermatomyositis: associations with... 6739049 - Low-vision aids for patients with suboptimal vision after closed vitrectomy for diabeti... 14697729 - Value of the implantable loop recorder for the management of patients with unexplained ... |
Publication Detail:
|
Type: Case Reports; Journal Article Date: 2009-05-13 |
Journal Detail:
|
Title: Clinical rheumatology Volume: 28 ISSN: 1434-9949 ISO Abbreviation: Clin. Rheumatol. Publication Date: 2009 Sep |
Date Detail:
|
Created Date: 2009-08-05 Completed Date: 2009-10-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8211469 Medline TA: Clin Rheumatol Country: Germany |
Other Details:
|
Languages: eng Pagination: 1113-6 Citation Subset: IM |
Affiliation:
|
Department of Rheumatology, Niigata Rheumatic Center, Shibata City, Niigata 957-0054, Japan. hiroe-212@umin.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Amyloidosis / complications*, pathology Antibodies, Monoclonal / administration & dosage* Arthritis, Rheumatoid / complications* Biopsy Diarrhea / drug therapy*, etiology*, pathology Female Humans Intestinal Mucosa / pathology Receptors, Interleukin-6 / immunology |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Monoclonal; 0/Receptors, Interleukin-6; 0/tocilizumab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antiphospholipid antibodies and kidney involvement in patients with systemic sclerosis.
Next Document: Measuring and benchmarking safety culture: application of the safety attitudes questionnaire to an a...