Document Detail

Tocainide therapy for refractory ventricular arrhythmias.
MedLine Citation:
PMID:  6770666     Owner:  NLM     Status:  MEDLINE    
Tocainide, a congener of lidocaine, was used to treat symptomatic ventricular arrhythmias in 19 patients resistant to or unable to tolerate conventional agents. In this highly selected group, 15 showed good initial responses to oral therapy. Ventricular tachycardia was suppressed to a greater extent than isolated ventricular ectopic depolarizations at any plasma concentration, and upward dose-ranging showed progressive suppression of both. Arrhythmia responsiveness to lidocaine was found to be an excellent predictor of tocainide response. Of the 15 responders, one died 24 hours after stopping therapy, three died while receiving tocainide, nine stopped because of adverse reactions (five allergic), and two continue on therapy at 1 and 4 years. We conclude that tocainide is an effective agent for the short-term suppression of ventricular arrhythmias, particularly ventricular tachycardia sensitive to lidocaine, but a high incidence of adverse effects limits its application to chronic therapy in many patients.
D M Roden; D M Roden; S B Reele; S B Reele; S B Higgins; S B Higgins; R K Carr; R K Carr; R F Smith; R F Smith; J A Oates; J A Oates; R L Woosley; R L Woosley
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American heart journal     Volume:  100     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1980-08-28     Completed Date:  1980-08-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  15-22     Citation Subset:  AIM; IM    
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MeSH Terms
Anilides / adverse effects,  therapeutic use*
Antibodies, Antinuclear
Arrhythmias, Cardiac / drug therapy*,  mortality
Dose-Response Relationship, Drug
Heart Ventricles / physiopathology
Lidocaine / therapeutic use
Middle Aged
Reg. No./Substance:
0/Anilides; 0/Antibodies, Antinuclear; 137-58-6/Lidocaine; 41708-72-9/Tocainide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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