Document Detail


Tocainide for refractory ventricular arrhythmias of myocardial infarction.
MedLine Citation:
PMID:  6778188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oral tocainide was used as a long-term antiarrhythmic in patients with symptomatic high-grade ventricular ectopic activity refractory to conventional antiarrhythmic agents. Eleven of the 22 patients had a previous myocardial infarction (three patients had a ventricular aneurysm). Unacceptable side effects precluded long-term use of tocainide in two patients. Long-term tocainide was effect in six of the remaining patients for periods of 9 days to 42.5 months (mean 15.2 months). Eight of these nine patients responded to intravenous lidocaine prior to tocainide therapy.
Authors:
C I Haffajee; J S Alpert; J E Dalen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  100     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-02-19     Completed Date:  1981-02-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1013-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Anilides / adverse effects,  metabolism,  therapeutic use*
Antibodies, Antinuclear
Arrhythmias, Cardiac / complications,  drug therapy*
Female
Heart Failure / mortality
Humans
Kinetics
Lidocaine / therapeutic use
Male
Myocardial Infarction / complications*,  drug therapy,  mortality
Tocainide
Chemical
Reg. No./Substance:
0/Anilides; 0/Antibodies, Antinuclear; 137-58-6/Lidocaine; 41708-72-9/Tocainide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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