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Tobacco smoking and risk of multiple myeloma: A meta-analysis of 40 observational studies.
MedLine Citation:
PMID:  23047159     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This meta-analysis aims to quantitatively synthesize all available data on the association between tobacco smoking and multiple myeloma (MM) risk. Eligible studies were identified and pooled effect estimates (odds ratios and relative risks) were calculated regarding ever, current and former smoking. Separate analyses were performed on case-control and cohort studies, as well as on males and females. Meta-regression analysis with percentage of males, mean age, years of smoking, pack-years, cigarettes per day, years since quit and age at onset was performed. 40 articles were deemed eligible; of them 27 used a case-control design (4,625 cases and 21,591 controls) and 13 used a cohort design (2,228 incident cases among a total cohort size equal to 1,852,763 subjects). Ever smoking was not associated with MM risk (pooled effect estimate= 0.92, 95%CI: 0.85-1.00); similar results were obtained for current (pooled effect estimate= 0.87, 95%CI: 0.74-1.03) and former smoking (pooled effect estimate= 1.04, 95%CI: 0.96-1.13). Regarding ever smoking, the null association was reproducible upon cohort studies (pooled effect estimate= 1.01, 95%CI: 0.89-1.15), whereas the inverse association in case-control studies (pooled effect estimate= 0.87, 95%CI: 0.78-0.96) was particularly due to the bias-prone hospital-based ones. Meta-regression analysis did not yield statistically significant results. In conclusion, MM does not seem to be associated with tobacco smoking. There is a need to further explore how molecular mechanisms are involved in the resistance of multiple myeloma progenitor cells towards smoking. © 2012 Wiley Periodicals, Inc.
Authors:
Theodora Psaltopoulou; Theodoros N Sergentanis; Nick Kanellias; Prodromos Kanavidis; Evangelos Terpos; Meletios A Dimopoulos
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-10
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  -     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 UICC.
Affiliation:
Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, M.Asias 75, Goudi, 11527, Athens, Greece. tpsaltop@med.uoa.gr.
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