Document Detail


Tobacco smoke exposure and allergic sensitization in children: a propensity score analysis.
MedLine Citation:
PMID:  22616936     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: There is conflicting evidence of the effect of environmental tobacco smoke (ETS) on the development of allergic diseases in children. Studies have shown that this relationship differs depending on maternal history of the disease. We employed the rigour of propensity score methods to assess this relationship using data from a birth cohort.
METHODS: Using n = 662 children from the Wayne County Health, Environment, Allergy and Asthma Longitudinal Study, we assessed the relationship between early-life ETS and subsequent allergic sensitization via a positive skin prick test (SPT+) or at least one specific immunoglobulin E (IgE) ≥ 0.35 (sIgE+) in children aged 2-3 years. Propensity score estimation followed by full and nearest neighbour matching was compared with standard multivariable regression models.
RESULTS: Among children without a maternal history of allergic disease, ETS was positively associated with allergic sensitization in children with an adjusted odds ratio (aOR) for SPT+ of 2.32 (95% confidence interval (CI): 1.28-4.22) and the aOR for sIgE+ was 2.53 (95% CI: 1.43-4.48). Contrarily, for children with a positive maternal history, the aOR for SPT+ and sIgE+ was 0.56 (95% CI: 0.24-1.32) and 0.43 (95% CI: 0.20-0.91), respectively.
CONCLUSIONS: Using propensity score methods to rigorously control for confounding factors, ETS exposure was found to reduce the risk of allergic sensitization in children with a positive maternal history. There is a strong association between early-life ETS and the development of allergic sensitization for children aged 2-3 years without maternal history.
Authors:
Suzanne L Havstad; Christine Cole Johnson; Edward M Zoratti; Jerel M Ezell; Kimberly Woodcroft; Dennis R Ownby; Ganesa Wegienka
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  17     ISSN:  1440-1843     ISO Abbreviation:  Respirology     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-21     Completed Date:  2013-02-26     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1068-72     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology.
Affiliation:
Department of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan, USA. shavsta1@hfhs.org
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MeSH Terms
Descriptor/Qualifier:
Child
Child, Preschool
Environmental Exposure / adverse effects*
Female
Humans
Hypersensitivity / epidemiology,  etiology*
Immunization
Immunoglobulin E
Male
Pregnancy
Propensity Score
Risk Factors
Skin Tests
Smoking / adverse effects*
Tobacco Smoke Pollution / adverse effects*
Grant Support
ID/Acronym/Agency:
P01 AI089473/AI/NIAID NIH HHS; R01 AI050681/AI/NIAID NIH HHS; R01 AI059415/AI/NIAID NIH HHS; R01AI50681/AI/NIAID NIH HHS; R21 AI059415/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Tobacco Smoke Pollution; 37341-29-0/Immunoglobulin E
Comments/Corrections
Comment In:
Respirology. 2012 Oct;17(7):1029-30   [PMID:  22862887 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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