| To what extent are the effects of diet on coronary heart disease lipid-mediated? | |
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MedLine Citation:
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PMID: 15159035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Cohort and case-control studies support the effect of diet on coronary heart disease. The objective of this study was to analyze the strength of the influence of dietary fat subtypes and other nutrients on serum lipids levels in patients with a first acute myocardial infarction. METHODS: We studied 139 patients with a first myocardial infarction and no previous history of vascular disease. Serum lipids were determined, and nutrient intake was analyzed using a validated 118-food item questionnaire. RESULTS: Multiple regression models found weak but significant associations between the intake of different fatty acids and total to HDL cholesterol ratio (atherogenic index) when we adjusted for age, gender and body mass index (BMI). Positive associations with serum HDL cholesterol concentration were observed for energy-adjusted intake of red wine, alcohol intake, and omega-3 fatty acids intake. However, these nutrients explained less than 12% of the variability in the atherogenic index, and less than 17% in the variability of HDL. CONCLUSIONS: Our results suggest only a modest contribution of the investigated nutrients on serum lipids (atherogenic index and HDL cholesterol) in coronary patients. Alternative mechanisms of dietary factors not directly related with serum lipids or, more likely, a global effect of diet on inflammatory and antioxidant parameters should be studied in order to better understand the nature of dietary habits' influence on cardiovascular disease. |
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Authors:
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M Serrano-Martinez; E Martinez-Losa; M Prado-Santamaria; C Brugarolas-Brufau; E Fernandez-Jarne; M A Martinez-Gonzalez |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: International journal of cardiology Volume: 95 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-05-25 Completed Date: 2004-11-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 35-8 Citation Subset: IM |
Affiliation:
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Department of Epidemiology and Public Health, Irunlarrea s/n, Facultad de Medicina, University of Navarre, 31080 Pamplona, Spain. mserranm@nacom.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Alcohol Drinking Biological Markers / blood Cholesterol, HDL / blood Coronary Disease / blood* Diet, Atherogenic Dietary Fats / administration & dosage*, metabolism* Energy Intake Fatty Acids, Monounsaturated / administration & dosage, metabolism Fatty Acids, Omega-3 / administration & dosage, metabolism Female Humans Lipids / blood* Male Middle Aged Multivariate Analysis Myocardial Infarction / blood Predictive Value of Tests Trans Fatty Acids / administration & dosage, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cholesterol, HDL; 0/Dietary Fats; 0/Fatty Acids, Monounsaturated; 0/Fatty Acids, Omega-3; 0/Lipids; 0/Trans Fatty Acids |
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