| To tube or not to tube babies with respiratory distress syndrome. | |
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MedLine Citation:
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PMID: 19399013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The use of mechanical ventilation in premature infants with respiratory distress syndrome (RDS) and respiratory failure often results in barotrauma, volutrauma and chronic lung disease (CLD). Research indicates that early surfactant therapy and initiation of nasal continuous positive airway pressure (CPAP) for these infants significantly reduces the need for mechanical ventilation and the incidence of CLD. Different CPAP delivery systems exist, each with some practical and clinical advantages and disadvantages. Clinical trials indicate that optimal management of neonatal RDS could be improved by early surfactant treatment followed immediately by extubation and stabilization on CPAP. Evidence suggests a synergistic effect between early surfactant administration (within 2 h of birth) and rapid extubation to nasal CPAP with a significant reduction in the need for mechanical ventilation and its associated morbidities. |
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Authors:
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K C Sekar; K E Corff |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 29 Suppl 2 ISSN: 1476-5543 ISO Abbreviation: J Perinatol Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-28 Completed Date: 2009-08-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: S68-72 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Neonatal-Perinatal Medicine, Neonatal Intensive Care Unit, Infant Breathing Disorders Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. kris-sekar@ouhsc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bronchopulmonary Dysplasia Combined Modality Therapy Continuous Positive Airway Pressure / instrumentation* Humans Infant, Newborn Intensive Care, Neonatal / methods* Intubation, Intratracheal* Pulmonary Surfactants / administration & dosage Randomized Controlled Trials as Topic Respiratory Distress Syndrome, Newborn / therapy* |
| Chemical | |
Reg. No./Substance:
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0/Pulmonary Surfactants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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