Document Detail


To tube or not to tube babies with respiratory distress syndrome.
MedLine Citation:
PMID:  19399013     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of mechanical ventilation in premature infants with respiratory distress syndrome (RDS) and respiratory failure often results in barotrauma, volutrauma and chronic lung disease (CLD). Research indicates that early surfactant therapy and initiation of nasal continuous positive airway pressure (CPAP) for these infants significantly reduces the need for mechanical ventilation and the incidence of CLD. Different CPAP delivery systems exist, each with some practical and clinical advantages and disadvantages. Clinical trials indicate that optimal management of neonatal RDS could be improved by early surfactant treatment followed immediately by extubation and stabilization on CPAP. Evidence suggests a synergistic effect between early surfactant administration (within 2 h of birth) and rapid extubation to nasal CPAP with a significant reduction in the need for mechanical ventilation and its associated morbidities.
Authors:
K C Sekar; K E Corff
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  29 Suppl 2     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-28     Completed Date:  2009-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S68-72     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Neonatal-Perinatal Medicine, Neonatal Intensive Care Unit, Infant Breathing Disorders Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. kris-sekar@ouhsc.edu
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MeSH Terms
Descriptor/Qualifier:
Bronchopulmonary Dysplasia
Combined Modality Therapy
Continuous Positive Airway Pressure / instrumentation*
Humans
Infant, Newborn
Intensive Care, Neonatal / methods*
Intubation, Intratracheal*
Pulmonary Surfactants / administration & dosage
Randomized Controlled Trials as Topic
Respiratory Distress Syndrome, Newborn / therapy*
Chemical
Reg. No./Substance:
0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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