| To treat or not to treat euthyroid autoimmune disorder during pregnancy? | |
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MedLine Citation:
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PMID: 19092255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Subclinical autoimmune hypothyroidism during pregnancy is associated with an increased risk of miscarriage and has a deleterious effect on fetal development. The aim of this study was to evaluate a screening and treatment strategy of subclinical hypothyroidism, and to establish normal ranges of thyroid-stimulating hormone (TSH) and thyroxine (T(4)) during pregnancy. METHODS: A retrospective study was carried out on 784 consecutive files of pregnant women; the files were systematically searched for thyroid function and antithyroid antibodies in order to determine the effect and the prevalence of anti-thyroid peroxidase antibodies (TPO-Ab) during pregnancy, and to evaluate treatment with levothyroxin (LT(4)) in TPO-Ab carriers. RESULTS: Among the 75 TPO-Ab-positive patients, 42 received LT(4) treatment during pregnancy. Although the range of TSH serum levels was wide, the mean TSH level was significantly higher in TPO-Ab-positive women (3 vs. 1 mIU/l, p < 0.01). No significant difference in the obstetrical complications rate was observed between TPO-Ab-positive and TPO-Ab-negative populations. CONCLUSIONS: Our study provides information on normal ranges of serum TSH and free T(4) for Belgian pregnant women receiving iodide supplementation. Based on our results, we suggest supplementation of TPO-Ab-positive pregnant women with 50 microg/day of LT(4), unless their TSH levels are lower than 1 mIU/l, to avoid the risk of hypothyroidism during pregnancy. |
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Authors:
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F Debiève; S Dulière; P Bernard; C Hubinont; P De Nayer; C Daumerie |
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Publication Detail:
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Type: Journal Article Date: 2008-12-18 |
Journal Detail:
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Title: Gynecologic and obstetric investigation Volume: 67 ISSN: 1423-002X ISO Abbreviation: Gynecol. Obstet. Invest. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-04-17 Completed Date: 2009-08-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7900587 Medline TA: Gynecol Obstet Invest Country: Switzerland |
Other Details:
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Languages: eng Pagination: 178-82 Citation Subset: IM |
Copyright Information:
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Copyright 2008 S. Karger AG, Basel. |
Affiliation:
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Department of Obstetrics, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium. debieve@obst.ucl.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autoantibodies
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blood Autoimmune Diseases / blood, diagnosis*, drug therapy, immunology Female Humans Hypothyroidism / blood, diagnosis*, drug therapy, immunology Iodide Peroxidase / immunology Pregnancy Pregnancy Complications / drug therapy, immunology* Retrospective Studies Thyrotropin / blood* Thyroxine / blood, therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin; EC 1.11.1.8/Iodide Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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