| To pool or not to pool, from whether to when: applications of pooling to biospecimens subject to a limit of detection. | |
| | |
MedLine Citation:
|
PMID: 18782255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Pooling of biological specimens has been utilised as a cost-efficient sampling strategy, but cost is not the unique limiting factor in biomarker development and evaluation. We examine the effect of different sampling strategies of biospecimens for exposure assessment that cannot be detected below a detection threshold (DT). The paper compares use of pooled samples to a randomly selected sample from a cohort in order to evaluate the efficiency of parameter estimates. The proposed approach shows that a pooling design is more efficient than a random sample strategy under certain circumstances. Moreover, because pooling minimises the amount of information lost below the DT, the use of pooled data is preferable (in a context of a parametric estimation) to using all available individual measurements, for certain values of the DT. We propose a combined design, which applies pooled and unpooled biospecimens, in order to capture the strengths of the different sampling strategies and overcome instrument limitations (i.e. DT). Several Monte Carlo simulations and an example based on actual biomarker data illustrate the results of the article. |
| | |
Authors:
|
Enrique F Schisterman; Albert Vexler |
Related Documents
:
|
15626375 - The effect of sampling design on extensive bryomonitoring surveys of air pollution. 11281425 - For what applications can probability and non-probability sampling be used? 18655035 - Experimental determination of sample stream focusing with fluorescent dye. 18979775 - Sample sufficiency and number of modes to retain in statistical shape modelling. 22408365 - Poisson growth mixture modeling of intensive longitudinal data: an application to smoki... 21258675 - Gps-yno2: computational prediction of tyrosine nitration sites in proteins. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Paediatric and perinatal epidemiology Volume: 22 ISSN: 1365-3016 ISO Abbreviation: Paediatr Perinat Epidemiol Publication Date: 2008 Sep |
Date Detail:
|
Created Date: 2008-09-10 Completed Date: 2008-11-28 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 8709766 Medline TA: Paediatr Perinat Epidemiol Country: England |
Other Details:
|
Languages: eng Pagination: 486-96 Citation Subset: IM |
Affiliation:
|
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA. schistee@mail.nih.gov |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analytic Sample Preparation Methods
/
methods* Biological Markers / analysis* Biometry Monte Carlo Method Sensitivity and Specificity |
| Grant Support | |
ID/Acronym/Agency:
|
Z01 HD008761-05/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Birth prevalence of congenital hypothyroidism in Mexico.
Next Document: A new strategy to induce effective antitumour response in vitro and in vivo.