Document Detail


To evaluate the efficacy of intrathecal magnesium sulphate for hysterectomy under subarachnoid block with bupivacaine and fentanyl: A prospective randomized double blind clinical trial.
MedLine Citation:
PMID:  23162399     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Intrathecal magnesium has been found to prolong the duration of analgesia in various surgical procedures like lower limb surgeries and as adjuncts to general anesthesia for pain management. The present study was designed to examine whether addition of intrathecal magnesium sulfate would enhance the analgesic efficacy of intrathecal bupivacaine and fentanyl in patients undergoing total abdominal hysterectomy.
METHODS: After taking informed consent, 60 patients were randomised into two groups with 30 patients. Group "S" received 2.5 mL (12.5 mg) of hyperbaric bupivacaine + 0.5 mL (25 mcg) of fentanyl + 0.5 mL of normal saline and Group "M" received 2.5 mL (12.5 mg) of hyperbaric bupivacaine + 0.5 mL (25 mcg) of fentanyl + 0.5 mL (100 mg) of magnesium sulfate. Onset of sensory, motor block and duration of analgesia was noted.
RESULTS: Demographic profile and duration of surgery were comparable (P>0.5). Time of onset of sensory and motor blockade was delayed in Group M compared with Group S, and this was statistically significant. A statistically significant longer duration of analgesia was observed in Group M compared with the control Group S. However, the recovery of motor blockade was found to be statistically insignificant in both the groups. The hemodynamic parameters were comparable in the perioperative period (P>0.05). The incidence of side-effects in both the groups were also comparable (P>0.05).
CONCLUSION: The addition of 100 mg intrathecal magnesium led to prolonged duration of analgesia significantly without increasing the incidence of side-effects. Also, there was a significant delay in the onset of both sensory and motor blockade.
Authors:
Mridu Paban Nath; Rakesh Garg; Tapan Talukdar; Dipika Choudhary; Anulekha Chakrabarty
Related Documents :
9707229 - Short-term tympanostomy in conjunction with hyperbaric oxygen therapy.
20629709 - C-reactive protein evolution in obstructive sleep apnoea patients under cpap therapy.
24180149 - Single dose of dexamethasone for prevention of nausea and vomiting after major gynaecol...
24326839 - Thoracoscopic lobectomy: comparison of intraoperative and postoperative outcomes betwee...
1572449 - Fibrosing alveolitis in an infant.
24847029 - The effect of narrowed gastric conduits on anastomotic leakage following minimally inva...
8393509 - The treatment of inclusion body myositis: a retrospective review and a randomized, pros...
22556199 - Midterm results of surgical hip dislocation for the treatment of femoroacetabular impin...
20850089 - Thrombosis of second-generation drug-eluting stents in real practice results from the m...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Saudi journal of anaesthesia     Volume:  6     ISSN:  0975-3125     ISO Abbreviation:  Saudi J Anaesth     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-11-19     Completed Date:  2012-11-20     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101500601     Medline TA:  Saudi J Anaesth     Country:  India    
Other Details:
Languages:  eng     Pagination:  254-8     Citation Subset:  -    
Affiliation:
Department of Anesthesiology and Critical Care, Gauhati Medical College Hospital, Guwahati, Assam, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Comparison of the use of McCoy and TruView EVO2 laryngoscopes in patients with cervical spine immobi...
Next Document:  Inadvertent endobronchial intubation: A sentinel event.