Document Detail

To eat or not to eat: the effect of AICAR on food intake regulation in yellow-bellied marmots (Marmota flaviventris).
MedLine Citation:
PMID:  20511516     Owner:  NLM     Status:  MEDLINE    
Mammals that hibernate (hibernators) exhibit a circannual rhythm of food intake and body mass. In the laboratory during the winter hibernation period, many hibernators enter a series of multi-day torpor bouts, dropping their body temperature to near ambient, and cease to feed even if food is present in their cage. The mechanism(s) that regulates food intake in hibernators is unclear. Recently, AMP-activated protein kinase (AMPK) has been shown to play a key role in the central regulation of food intake in mammals. We hypothesized that infusing an AMPK activator, 5-aminoimidazole-4-carboxamide 1 B-D-ribofuranoside (AICAR), intracerebroventricularly (ICV) into the third ventricle of the hypothalamus would stimulate yellow-bellied marmots (Marmota flaviventris) to feed during their hibernation season. Infusion of AICAR ICV into marmots at an ambient temperature of 22 degrees C caused a significant (P<0.05) increase in food intake. In addition, animals stimulated to feed did not enter torpor during the infusion period. Marmots ICV infused with saline did not increase food intake and these animals continued to undergo torpor at an ambient temperature of 22 degrees C. Our results suggest that AICAR stimulated the food intake pathway, presumably by activating AMPK. These results support the hypothesis that AMPK may be involved in regulating food intake in hibernators and that there may be common neural pathways involved in regulating feeding and eliciting torpor.
Gregory L Florant; Ashley M Fenn; Jessica E Healy; Gregory K Wilkerson; Robert J Handa
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of experimental biology     Volume:  213     ISSN:  1477-9145     ISO Abbreviation:  J. Exp. Biol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-09-01     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0243705     Medline TA:  J Exp Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2031-7     Citation Subset:  IM    
Department of Biology, Colorado State University, Fort Collins, CO 80523, USA.
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MeSH Terms
Aminoimidazole Carboxamide / analogs & derivatives*,  pharmacology
Appetite Regulation / drug effects*
Body Temperature / drug effects,  physiology
Body Weight / drug effects
Feeding Behavior / drug effects
Marmota / physiology*
Ribonucleotides / pharmacology*
Sodium Chloride / pharmacology
Grant Support
Reg. No./Substance:
0/Ribonucleotides; 360-97-4/Aminoimidazole Carboxamide; 7647-14-5/Sodium Chloride; F0X88YW0YK/AICA ribonucleotide

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