| To B or not to B cells-mediate a healthy start to life. | |
| | |
MedLine Citation:
|
PMID: 23286939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Maternal immune responses during pregnancy are critical in programming the future health of a newborn. The maternal immune system is required to accommodate fetal immune tolerance as well as to provide a protective defence against infections for the immunocompromised mother and her baby during gestation and lactation. Natural immunity and antibody production by maternal B cells play a significant role in providing such immunoprotection. However, aberrations in the B cell compartment as a consequence of maternal autoimmunity can pose serious risks to both the mother and her baby. Despite their potential implication in shaping pregnancy outcomes, the role of B cells in human pregnancy has been poorly studied. This review focuses on the role of B cells and the implications of B cell depletion therapy in pregnancy. It highlights the evidence of an association between aberrant B cell compartment and obstetric conditions. It also alludes to the potential mechanisms that amplify these B cell aberrances and thereby contribute to exacerbation of some maternal autoimmune conditions and poor neonatal outcomes. Clinical and experimental evidence suggests strongly that maternal autoantibodies contribute directly to the pathologies of obstetric and neonatal conditions that have significant implications for the lifelong health of a newborn. The evidence for clinical benefit and safety of B cell depletion therapies in pregnancy is reviewed, and an argument is mounted for further clinical evaluation of B cell-targeted therapies in high-risk pregnancy, with an emphasis on improving neonatal outcomes and prevention of neonatal conditions such as congenital heart block and fetal/neonatal alloimmune thrombocytopenia. |
| | |
Authors:
|
T G Nguyen; C M Ward; J M Morris |
Related Documents
:
|
21861949 - Does vitamin d during pregnancy impact offspring growth and bone? 264369 - Successful treatment of acute leukemia during pregnancy. combination therapy in the thi... 23001209 - Antigen presenting cells costimulatory signaling during pre-implantation pregnancy . 21789529 - Pregnancy and acromegaly: a review. 10385569 - Relapse of acute lymphoblastic leukemia in pregnancy: survival following chemoirradiati... 16877239 - Hypertriglyceridemia-associated acute pancreatitis with chylous ascites in pregnancy. 49759 - Induced abortion and subsequent outcome of pregnancy. a matched cohort study. 9194639 - Serum concentrations of oestradiol-17beta, progesterone, relaxin and chorionic gonadotr... 8463159 - Effects of sire and dam on late-pregnancy conceptus and hormone traits in beef cattle. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Clinical and experimental immunology Volume: 171 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-01-04 Completed Date: 2013-03-12 Revised Date: 2013-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
|
Languages: eng Pagination: 124-34 Citation Subset: IM |
Copyright Information:
|
© 2012 British Society for Immunology. |
Affiliation:
|
Perinatal Research, Kolling Institute of Medical Research, North Shore Hospital, Sydney, Australia. tommie.nguyen@sydney.edu.au |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antibody Formation Autoantibodies / immunology B-Lymphocytes / immunology* Female Heart Block / congenital*, immunology, therapy Humans Immune Tolerance Immunity, Innate Immunity, Maternally-Acquired Infant, Newborn Infection / immunology*, therapy Lymphocyte Depletion Pregnancy Pregnancy Complications / immunology*, therapy Thrombocytopenia, Neonatal Alloimmune / immunology*, therapy |
| Chemical | |
Reg. No./Substance:
|
0/Autoantibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Immune mechanisms and the impact of the disrupted lung microbiome in chronic bacterial lung infectio...
Next Document: Cell-based interventions to halt autoimmunity in type 1 diabetes mellitus.