Document Detail

Collectrin and ACE2 in renal and intestinal amino acid transport.
MedLine Citation:
PMID:  21814048     Owner:  NLM     Status:  MEDLINE    
Neutral amino acid transporters of the SLC6 family are expressed at the apical membrane of kidney and/or small intestine, where they (re-)absorb amino acids into the body. In this review we present the results concerning the dependence of their apical expression with their association to partner proteins. We will in particular focus on the situation of B0AT1 and B0AT3, that associate with members of the renin-angiotensin system (RAS), namely Tmem27 and angiotensin-converting enzyme 2 (ACE2), in a tissue specific manner. The role of this association in relation to the formation of a functional unit related to Na+ or amino acid transport will be assessed. We will conclude with some remarks concerning the relevance of this association to Hartnup disorder, where some mutations have been shown to differentially interact with the partner proteins.
Dustin Singer; Simone M R Camargo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-09-01
Journal Detail:
Title:  Channels (Austin, Tex.)     Volume:  5     ISSN:  1933-6969     ISO Abbreviation:  Channels (Austin)     Publication Date:    2011 Sep-Oct
Date Detail:
Created Date:  2011-10-19     Completed Date:  2012-02-14     Revised Date:  2012-03-16    
Medline Journal Info:
Nlm Unique ID:  101321614     Medline TA:  Channels (Austin)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  410-23     Citation Subset:  IM    
INRA/AgroParisTech, Paris, France.
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MeSH Terms
Amino Acid Transport Systems, Neutral / genetics,  metabolism
Amino Acids / genetics,  metabolism*
Biological Transport / physiology
Hartnup Disease / genetics,  metabolism
Intestine, Small / metabolism*
Kidney / metabolism*
Membrane Glycoproteins / genetics,  metabolism*
Organ Specificity / physiology
Peptidyl-Dipeptidase A / genetics,  metabolism*
Renin-Angiotensin System / physiology
Sodium / metabolism
Reg. No./Substance:
0/Amino Acid Transport Systems, Neutral; 0/Amino Acids; 0/Membrane Glycoproteins; 0/SLC6A19 protein, human; 0/SLC6A19 protein, mouse; 0/TMEM27 protein, human; 0/Tmem27 protein, mouse; 7440-23-5/Sodium; EC A; EC 3.4.17.-/angiotensin converting enzyme 2

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