| Tmem176B and Tmem176A are associated with the immature state of dendritic cells. | |
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MedLine Citation:
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PMID: 20501748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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DCs play a central role in the development of innate and adaptive immunity but also in the induction and maintenance of immune tolerance. Identification of factors that govern DC activation, their maturation state, and their capacity to induce proinflammatory or tolerogeneic responses therefore represents a crucial aim of research. We previously identified a new molecule, Tmem176B (which we named TORID initially), as highly expressed in a model of allograft tolerance in the rat. We showed that its overexpression in rat DCs blocked their maturation, suggesting a role for this molecule in the maturation process. To characterize the function of Tmem176B further, we used a split-ubiquitin yeast, two-hybrid system to identify interacting partners and found that Tmem176B associated with itself but also with Tmem176A, a membrane protein similar to Tmem176B. Interestingly, these two molecules showed similar mRNA expression patterns among various murine tissues and immune cells and were both down-regulated following DC maturation. In addition, we showed that in using RNAi, these molecules are both involved in the maintenance of the immature state of the DCs. Taken together, these data suggest that Tmem176B and Tmem176A associate to form multimers and restrain DC maturation. Therefore, these two molecules may represent valid targets to regulate DC function. |
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Authors:
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Thomas Condamine; Laetitia Le Texier; Duncan Howie; Amelie Lavault; Marcelo Hill; Frank Halary; Steve Cobbold; Herman Waldmann; Maria-Cristina Cuturi; Elise Chiffoleau |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-25 |
Journal Detail:
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Title: Journal of leukocyte biology Volume: 88 ISSN: 1938-3673 ISO Abbreviation: J. Leukoc. Biol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-02 Completed Date: 2010-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8405628 Medline TA: J Leukoc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 507-15 Citation Subset: IM |
Affiliation:
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INSERM, U643, CHU Nantes, Institut de Transplantation et de Recherche en Transplantation, ITERT, and Université de Nantes, Faculté de Médecine, Nantes, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation* / genetics Cell Proliferation Dendritic Cells / cytology*, metabolism*, secretion Gene Expression Profiling Gene Expression Regulation Interleukin-6 / secretion Membrane Proteins / chemistry, genetics, metabolism* Mice Mice, Inbred BALB C Mice, Inbred C57BL Organ Specificity Phenotype Protein Binding RNA Interference T-Lymphocytes / cytology, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/Membrane Proteins; 0/Tmem176A protein, mouse; 0/Tmem176B protein, mouse |
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