| Tl-201 washout rate in remote normal regions in patients with prior myocardial infarction and left ventricular remodeling. | |
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MedLine Citation:
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PMID: 15812372 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Myocardial characteristics of remote normal regions in patients with myocardial infarction (MI) and left ventricular (LV) remodeling have not been fully elucidated. Thus, we investigated this issue from the viewpoint of myocardial Tl-201 dynamics. METHODS AND RESULTS: In 14 patients with prior anterior MI, 10 with inferior MI, and 14 age-matched patients with atypical chest pain served as controls; exercise stress Tl-201 SPECT and cardiac catheterization were performed. Tl-201 washout rate was calculated for 8 myocardial segments, and LV end-diastolic volume index was obtained as a parameter of LV remodeling. LV end-diastolic volume index was greater in anterior MI patients than in control patients; in contrast, no significant difference was observed between inferior MI patients and control patients. The washout rate in remote normal regions was significantly less in anterior MI patients than in the corresponding segments in control patients (39.8% +/- 8.7% vs 48.4% +/- 4.4%, P < .01). There was no significant difference between inferior MI patients and control patients (43.6% +/- 6.9% vs 47.8% +/- 4.5%). CONCLUSIONS: Reduced Tl-201 washout rates in remote normal regions are found in patients with anterior MI and LV remodeling. Subclinical myocardial ischemia during exercise in remote normal regions exists and may be related to the pathologic condition of such LV walls. |
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Authors:
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Toshihiko Goto; Nobuyuki Ohte; Hiromichi Miyabe; Seiji Mukai; Seiichiro Sakata; Junichiro Hayano; Genjiro Kimura |
Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology Volume: 12 ISSN: 1071-3581 ISO Abbreviation: J Nucl Cardiol Publication Date: 2005 Mar-Apr |
Date Detail:
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Created Date: 2005-04-06 Completed Date: 2005-07-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423534 Medline TA: J Nucl Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 179-85 Citation Subset: IM |
Affiliation:
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Departmernt of Internal Medicine and Pathophysiology, Graduate School of Medical Sciences, Nagoya City University, Nagoya City 467-8601, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Exercise Test Female Humans Image Interpretation, Computer-Assisted / methods* Male Metabolic Clearance Rate Myocardial Infarction / complications, metabolism*, radionuclide imaging* Prognosis Radiopharmaceuticals / diagnostic use, pharmacokinetics Reproducibility of Results Risk Assessment / methods Risk Factors Sensitivity and Specificity Thallium / diagnostic use*, pharmacokinetics* Tomography, Emission-Computed, Single-Photon / methods Ventricular Dysfunction, Left / etiology, metabolism*, radionuclide imaging* Ventricular Remodeling* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 7440-28-0/Thallium; 7791-12-0/thallium chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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