Document Detail


Title: Review of the Fibrinolytic System: Comparison of Different Antifibrinolytics used During Cardiopulmonary Bypass.
MedLine Citation:
PMID:  23035827     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Antifibrinolytic agents are often used in different clinical situations, especially in cardiac surgery. During several years, aprotinin was the drug of choice because more than antifibrinolytic properties, aprotinin offers a direct effect on kallikrein and inflammatory pathways. In 2008, The Blood Conservation Using Antifibrinolytics in a Randomized Trial (BART) initiated a discussion about real risks associated with aprotinin administration. Tranexamic acid and epsilon- aminocaproic acid appear to be interesting alternatives in our daily practice. The exact mechanism of action, the pharmacokinetic parameters, the efficacy, and the safety profile need to be clarified for lysine analogs. In this review, the different antifibrinolytics will be described with a special interest into the route of work, and recent patents. Current studies about the pharmacokinetic and the pharmacodynamic profile will be described, and finally the benefit-to-risk balance in patients undergoing cardiac surgery with cardiopulmonary bypass will be discussed.
Authors:
Caroline Van Aelbrouck; Lars Englberger; David Faraoni
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-01
Journal Detail:
Title:  Recent patents on cardiovascular drug discovery     Volume:  -     ISSN:  2212-3962     ISO Abbreviation:  Recent Pat Cardiovasc Drug Discov     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101263805     Medline TA:  Recent Pat Cardiovasc Drug Discov     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Anesthesiology. Queen Fabiola Childrens University Hospital. 15 Avenue JJ Crocq. 1020 Brussels, Belgium. davidfaraoni@me.com.
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