Document Detail

Titanium Topography Controls FoxO/{beta}-catenin Signaling.
MedLine Citation:
PMID:  21297018     Owner:  NLM     Status:  In-Data-Review    
Little is known about how surface topography can modulate mesenchymal cell responses to oxygen-related stress occurring with age, or during the early phases of wound healing or inflammation. To antagonize Reactive Oxygen Species (ROS), cells resort to defense mechanisms, relying on β-catenin, a molecular switch between a TCF-mediated pathway, which promotes cells proliferation and commitment, and an alternative one controlled by FoxO, which induces quiescence and defenses against ROS. In the present study, we show that mesenchymal C2C12 cells are protected from H(2)O(2)-induced oxidative stress when they grow on rough (SLA) titanium surfaces. The expression of anti-ROS genes and FoxO/β-catenin signaling, as measured by a reporter assay, were increased on SLA surfaces. We also show that TCF-mediated transcription was inhibited by ROS in cells growing on either smooth or SLA titanium. Our results demonstrate that surface topography modulates cell resistance to ROS and the balance between the molecular pathways regulating cell growth and cell defense against oxidative stress.
C Galli; G M Macaluso; M Piemontese; G Passeri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of dental research     Volume:  90     ISSN:  1544-0591     ISO Abbreviation:  J. Dent. Res.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0354343     Medline TA:  J Dent Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  360-4     Citation Subset:  D; IM    
Sez. Odontostomatologia, University of Parma, Via Gramsci 14, 43100 Parma, Italy.
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