Document Detail


Titan cells confer protection from phagocytosis in Cryptococcus neoformans infections.
MedLine Citation:
PMID:  22544904     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human fungal pathogen Cryptococcus neoformans produces an enlarged "titan" cell morphology when exposed to the host pulmonary environment. Titan cells exhibit traits that promote survival in the host. Previous studies showed that titan cells are not phagocytosed and that increased titan cell production in the lungs results in reduced phagocytosis of cryptococcal cells by host immune cells. Here, the effect of titan cell production on host-pathogen interactions during early stages of pulmonary cryptococcosis was explored. The relationship between titan cell production and phagocytosis was found to be nonlinear; moderate increases in titan cell production resulted in profound decreases in phagocytosis, with significant differences occurring within the first 24 h of the infection. Not only were titan cells themselves protected from phagocytosis, but titan cell formation also conferred protection from phagocytosis to normal-size cryptococcal cells. Large particles introduced into the lungs were not phagocytosed, suggesting the large size of titan cells protects against phagocytosis. The presence of large particles was unable to protect smaller particles from phagocytosis, revealing that titan cell size alone is not sufficient to provide the observed cross-protection of normal-size cryptococcal cells. These data suggest that titan cells play a critical role in establishment of the pulmonary infection by promoting the survival of the entire population of cryptococcal cells.
Authors:
Laura H Okagaki; Kirsten Nielsen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-04-27
Journal Detail:
Title:  Eukaryotic cell     Volume:  11     ISSN:  1535-9786     ISO Abbreviation:  Eukaryotic Cell     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-30     Completed Date:  2012-10-31     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  101130731     Medline TA:  Eukaryot Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  820-6     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cross Protection / immunology
Cryptococcosis / immunology*,  microbiology*,  pathology
Cryptococcus neoformans / cytology*,  physiology*
Cytoprotection*
Female
Humans
Mice
Mice, Inbred C57BL
Nonlinear Dynamics
Phagocytosis*
Grant Support
ID/Acronym/Agency:
AI080275/AI/NIAID NIH HHS; R01 AI080275/AI/NIAID NIH HHS
Comments/Corrections

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