Document Detail


Tissue uptake of thyroid hormone by amino acid transporters.
MedLine Citation:
PMID:  17574006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thyroid hormones (THs) -- thyroxine (T4) and tri-iodothyronine (T3) -- are iodinated derivatives of the amino acid tyrosine, which regulates growth, development and critical metabolic functions. THs are taken up by target cells and act at the genomic level via nuclear thyroid receptors. Saturable transport mechanisms mediate the greater part of TH movement across the plasma membrane. System L1 permease is a transporter of THs and amino acids in mammalian adipose tissue, placenta and brain. T(3) is also a substrate of a putative System T transporter, which is selective for aromatic amino acids. The activity and functional mechanisms of these transporters can be crucial to cells in determining both their hormone sensitivity and their responses to change in circulating hormone concentrations or availability of competing substrates (e.g. amino acids). TH transporters are potentially important pharmacological targets in the design of novel or improved therapies for thyroid-related disorders.
Authors:
Peter M Taylor; James W A Ritchie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Best practice & research. Clinical endocrinology & metabolism     Volume:  21     ISSN:  1521-690X     ISO Abbreviation:  Best Pract. Res. Clin. Endocrinol. Metab.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-18     Completed Date:  2007-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120682     Medline TA:  Best Pract Res Clin Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  237-51     Citation Subset:  IM    
Affiliation:
Division of Molecular Physiology, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, UK. p.m.taylor@dundee.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adipose Tissue / metabolism
Amino Acid Transport Systems / metabolism*,  physiology
Animals
Biological Transport
Blood-Brain Barrier / metabolism
Humans
Models, Biological
Organ Specificity
Phenylketonurias / metabolism
Placenta / metabolism
Thyroid Hormones / metabolism*,  pharmacology
Tryptophan / deficiency,  metabolism
Chemical
Reg. No./Substance:
0/Amino Acid Transport Systems; 0/Thyroid Hormones; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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