Document Detail

Tissue-type plasminogen activator -7,351C/T enhancer polymorphism is associated with a first myocardial infarction.
MedLine Citation:
PMID:  11848437     Owner:  NLM     Status:  MEDLINE    
We recently identified a polymorphic Sp1 binding site in an enhancer at the tissue-type plasminogen activator (tPA) locus (tPA -7,351C/T), which was associated with vascular tPA release. Subjects homozygous for the -7,351C allele had twice the tPA release rate compared to subjects carrying the -7,351T allele. In this study we tested the hypothesis that the tPA -7,351C/T polymorphism is associated with myocardial infarction (MI). In a population-based prospective nested case-control study within northern Sweden, genotypes were determined among 61 MI cases and 120 controls. In a multivariate model, the tPA -7,351C/T polymorphism (OR 2.68 for T allele carriers; 95% CI 1.31-5.50), tPA antigen (OR 1.16; 95% CI 1.07-1.25) and apo A-I (OR, 0.997; 95% CI 0.995-0.999) were independently associated with a first MI. These findings suggest that genetic markers of local tPA release and circulating steady-state tPA levels carry independent prognostic information.
Per Ladenvall; Lars Johansson; Jan-Håkan Jansson; Sverker Jern; Torbjörn K Nilsson; Anna Tjärnlund; Christina Jern; Kurt Boman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  87     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-18     Completed Date:  2002-08-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  105-9     Citation Subset:  IM    
Cardiovascular Institute, Clinical Experimental Research Laboratory, Sahlgrenska University Hospital/Ostra, Göteborg University, Sweden.
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MeSH Terms
Apolipoprotein A-I / analysis
Binding Sites
Cardiovascular Diseases / epidemiology
Case-Control Studies
Enhancer Elements, Genetic / genetics*
Genetic Predisposition to Disease
Health Surveys
Hypertension / epidemiology
Intervention Studies
Middle Aged
Multivariate Analysis
Myocardial Infarction / epidemiology,  genetics*
Obesity / epidemiology
Odds Ratio
Plasminogen Activator Inhibitor 1 / analysis
Polymorphism, Genetic
Prospective Studies
Risk Factors
Sp1 Transcription Factor / metabolism
Sweden / epidemiology
Tissue Plasminogen Activator / genetics*,  secretion
Reg. No./Substance:
0/Apolipoprotein A-I; 0/Plasminogen Activator Inhibitor 1; 0/Sp1 Transcription Factor; EC Plasminogen Activator

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