Document Detail


Tissue-specific regulation of inflammation.
MedLine Citation:
PMID:  1371501     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Proteins of the complement system are important effectors and modulators of inflammation. The complement cascade is triggered by microbes, tissue debris, and specific antibodies. Serum complement proteins are derived primarily from liver, but extrahepatic complement synthesis is important in homeostasis and in local host defenses. Tissue-specific regulation of expression of complement genes is governed by mechanisms similar to those that regulate other "acute phase reactants." That is, tissue injury or infection elicit changes in expression of these acute phase proteins, which, although variable in kinetics, magnitude, and direction, are a consequence of an elaborate system of cell-to-cell communication. This communication is mediated via a complex network of cytokines, including the interferons, interleukins, several growth factors, and sex hormones. The cell biological and molecular biological details of these mechanisms are now under active investigation. An understanding in molecular terms of the balance between proinflammatory and counterregulatory forces on complement gene expression should provide new insight into the functions of complement and the design of novel therapies for disorders of inflammation.
Authors:
H R Colten
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  72     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-03-30     Completed Date:  1992-03-30     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110.
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MeSH Terms
Descriptor/Qualifier:
Acute-Phase Proteins / genetics,  physiology
Animals
Complement System Proteins / genetics,  physiology
Cytokines / physiology
Gene Expression
Humans
Inflammation / genetics,  immunology,  physiopathology*
Chemical
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Cytokines; 9007-36-7/Complement System Proteins

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