Document Detail

Tissue-specific high-level expression of human endogenous retrovirus-R in the human adrenal cortex.
MedLine Citation:
PMID:  9732235     Owner:  NLM     Status:  MEDLINE    
In an attempt to clarify the biological nature of a human endogenous retrovirus (HERV), HERV-R, which is a single-copy type of HERVs and is conserved as a full-length viral sequence, the expression of HERV-R mRNA in normal autopsied systemic organs was examined by Northern blot analysis. The expression showed different levels among individuals, with the adrenal glands expressing the highest level of HERV-R among all organs tested, except for the placenta. In various adrenal tumors, HERV-R was expressed at high levels in all cortical adenomas but less so in pheochromocytomas. In situ hybridization revealed the expression of HERV-R to be localized in all layers of the adrenal cortex, but not in the medulla. This high-level expression of HERV-R in the adrenal cortex may possibly relate to differentiation and/or steroid production by adrenocortical cells.
K Katsumata; H Ikeda; M Sato; H Harada; A Wakisaka; M Shibata; T Yoshiki
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pathobiology : journal of immunopathology, molecular and cellular biology     Volume:  66     ISSN:  1015-2008     ISO Abbreviation:  Pathobiology     Publication Date:  1998  
Date Detail:
Created Date:  1998-11-05     Completed Date:  1998-11-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9007504     Medline TA:  Pathobiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  209-15     Citation Subset:  IM    
Department of Pathology, Hokkaido University School of Medicine, Sapporo, Japan.
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MeSH Terms
Adrenal Cortex / virology*
Adrenal Gland Neoplasms / virology
Adrenal Glands / virology
Blotting, Northern
Endogenous Retroviruses / genetics,  isolation & purification*
Gene Expression
In Situ Hybridization
Middle Aged
Placenta / virology
Proviruses / genetics,  isolation & purification*
RNA, Messenger / analysis
Transcription, Genetic
Reg. No./Substance:
0/RNA, Messenger

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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