Document Detail


Tissue-specific functions in the fatty acid-binding protein family.
MedLine Citation:
PMID:  20716527     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The intracellular fatty acid-binding proteins (FABPs) are abundantly expressed in almost all tissues. They exhibit high affinity binding of a single long-chain fatty acid, with the exception of liver FABP, which binds two fatty acids or other hydrophobic molecules. FABPs have highly similar tertiary structures consisting of a 10-stranded antiparallel β-barrel and an N-terminal helix-turn-helix motif. Research emerging in the last decade has suggested that FABPs have tissue-specific functions that reflect tissue-specific aspects of lipid and fatty acid metabolism. Proposed roles for FABPs include assimilation of dietary lipids in the intestine, targeting of liver lipids to catabolic and anabolic pathways, regulation of lipid storage and lipid-mediated gene expression in adipose tissue and macrophages, fatty acid targeting to β-oxidation pathways in muscle, and maintenance of phospholipid membranes in neural tissues. The regulation of these diverse processes is accompanied by the expression of different and sometimes multiple FABPs in these tissues and may be driven by protein-protein and protein-membrane interactions.
Authors:
Judith Storch; Alfred E Thumser
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-08-17
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  285     ISSN:  1083-351X     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-18     Completed Date:  2010-11-24     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  32679-83     Citation Subset:  IM    
Affiliation:
Department of Nutritional Sciences and the Rutgers Center for Lipid Research, Rutgers University, New Brunswick, New Jersey 08901, USA. storch@aesop.rutgers.edu
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism
Animals
Dietary Fats / metabolism*
Fatty Acid-Binding Proteins / physiology*
Fatty Acids / metabolism*
Gene Expression Regulation / physiology*
Helix-Turn-Helix Motifs
Humans
Intestines / metabolism
Lipid Metabolism / physiology*
Liver / metabolism
Macrophages / metabolism
Muscles / metabolism
Organ Specificity / physiology
Oxidation-Reduction
Protein Binding / physiology
Grant Support
ID/Acronym/Agency:
DK38389/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acid-Binding Proteins; 0/Fatty Acids
Comments/Corrections

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