Document Detail


Tissue-specific and fatty acid transporter-specific changes in heart and soleus muscle over a 1-yr period.
MedLine Citation:
PMID:  16718359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rates of fatty acid oxidation increase rapidly in both rat heart and skeletal muscle in the early postnatal period. Therefore, we examined in heart and soleus muscle, (a) whether there were rapid changes in fatty acid transporter (FAT/CD36, FABPpm) mRNA and protein expression early in life (days 10 -36) and thereafter (days 84, 160, 365), and (b) whether the rates of fatty acid transport and the plasmalemmal content of FAT/CD36 and FABPpm were altered. Protein expression was altered rapidly from day 10-36 in both heart (FAT/CD36 only, +21%, P < 0.05)) and soleus muscle (FAT/CD36 + 100%, P < 0.05; FABPpm -20%, P < 0.05), with no further changes thereafter (P < 0.05). Rates of fatty acid transport (day 10 vs day 160) were increased in heart (+33%, P < 0.05) and muscle (+85%, P < 0.05), and were associated with concomitant increases in plasmalemmal FABPpm (+44%, P < 0.05) and FAT/CD36 (+16%, P < 0.05) in the heart, and only plasmalemmal FAT/CD36 in muscle (+90%, P < 0.05). Therefore, known changes in the rates of fatty acid oxidation in heart and muscle early in life appear to be accompanied by a concurrent upregulation in the rates of fatty acid transport and the expression of FAT/CD36 in heart and muscle, as well as an increase in plasmalemmal FAT/CD36 and FABPpm in the heart, and only plasmalemmal FAT/CD36 in soleus muscle. We speculate that the rapid upregulation of fatty acid transport rates in heart and muscle are needed to support the increased rates of fatty oxidation that have been previously observed in these tissues.
Authors:
Arend Bonen; James G Nickerson; Iman Momken; Adrian Chabowski; Jorge Calles-Escandon; Narendra N Tandon; Jan F C Glatz; Joost J F P Luiken
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-23
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  291     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-12     Completed Date:  2006-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  145-54     Citation Subset:  IM    
Affiliation:
Department of Human Health and Nutritional Sciences University of Guelph, Guelph, Ontario, N1G 2W1, Canada. abonen@uoguelph.ca
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MeSH Terms
Descriptor/Qualifier:
3-Hydroxyacyl CoA Dehydrogenases / metabolism
Animals
Animals, Newborn
Antigens, CD36 / genetics,  metabolism*
Biological Transport
Citrate (si)-Synthase / metabolism
Fatty Acid-Binding Proteins / genetics,  metabolism*
Gene Expression Regulation
Male
Muscle, Skeletal / enzymology,  metabolism*
Myocardium / enzymology,  metabolism*
Organ Specificity
RNA, Messenger / genetics,  metabolism
Rats
Rats, Sprague-Dawley
Sarcolemma / metabolism
Time Factors
Chemical
Reg. No./Substance:
0/Antigens, CD36; 0/Fatty Acid-Binding Proteins; 0/RNA, Messenger; EC 1.1.1.35/3-Hydroxyacyl CoA Dehydrogenases; EC 2.3.3.1/Citrate (si)-Synthase

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