Document Detail

Tissue-specific differentiation of a circulating CCR9- pDC-like common dendritic cell precursor.
MedLine Citation:
PMID:  22547585     Owner:  NLM     Status:  Publisher    
The ontogenic relationship between the common dendritic cell (DC) progenitor, the committed conventional DC precursor (pre-cDC) and cDC subpopulations in lymphoid and non-lymphoid tissues have been largely unraveled. In contrast, the sequential steps of plasmacytoid DC (pDC) development are less defined and it is unknown at which developmental stage and location final commitment to the pDC lineage occurs. Here we show that CCR9- pDCs from murine bone marrow which enter the circulation and peripheral tissues have a common DC precursor function in vivo in the steady state in contrast to CCR9+ pDCs which are terminally differentiated. Upon adoptive transfer the fate of CCR9- pDC-like precursors is governed by the tissues they enter. In the bone marrow and liver most transferred CCR9- pDC-like precursors differentiate into CCR9+ pDCs, whereas in peripheral lymphoid organs, lung and intestine they additionally give rise to cDCs. CCR9- pDC-like precursors which are distinct from pre-cDCs can be generated from the CDP. Thus, CCR9- pDC-like cells are novel CDP-derived circulating DC precursors with pDC and cDC potential. Their final differentiation into functionally distinct pDCs and cDCs depends on tissue-specific factors allowing adaptation to local requirements under homeostatic conditions.
Andreas Schlitzer; Alexander F Heiseke; Henrik Einwächter; Wolfgang Reindl; Matthias Schiemann; Calin-Petru Manta; Peter See; Jan Hendrik Niess; Tobias Suter; Florent Ginhoux; Anne B Krug
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-30
Journal Detail:
Title:  Blood     Volume:  -     ISSN:  1528-0020     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-5-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
II. Medical Department, Klinikum rechts der Isar, Technical University Munich, Germany;
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