Document Detail


Tissue specific delivery of estrone-conjugated siRNAs.
MedLine Citation:
PMID:  23037688     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
An estrone phosphoramidite, synthesized in a single step, was directly incorporated at the 5' ends of small interfering RNAs (siRNAs). The resulting estrone-conjugated siRNAs readily pass through cellular membranes and down-regulate the target protein, and show specific distributions in vivo.
Authors:
Eun-Kyoung Bang; Eun Mi Jeon; Wanil Kim; Kyung-Ha Lee; Kyong-Tai Kim; Byeang Hyean Kim
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-5
Journal Detail:
Title:  Molecular bioSystems     Volume:  -     ISSN:  1742-2051     ISO Abbreviation:  Mol Biosyst     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101251620     Medline TA:  Mol Biosyst     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Chemistry, BK School of Molecular Science, Pohang University of Science and Technology, Pohang 790-784, Korea. bhkim@postech.ac.kr.
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