| Tissue-specific changes in protein synthesis rates in vivo during anoxia in crucian carp. | |
| | |
MedLine Citation:
|
PMID: 8897979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Mechanisms of anoxia tolerance were investigated in crucian carp. Rates of protein synthesis were calculated in selected tissues of normoxic and anoxic animals. Exposure to 48 h of anoxia resulted in a significant reduction in protein synthesis in the liver (> 95%), heart (53%), and red and white muscle (52 and 56%, respectively), whereas brain protein synthesis rates were unaffected. Seven days of anoxia produced similar results. After 24 h of recovery from a 48-h anoxic period, protein synthesis rates had virtually returned to normoxic values. The effect of anoxia on the amount of RNA (relative to protein) varied depending on the tissue and also the length of exposure (except in the brain, where it was consistently reduced). However, the effect on RNA translational efficiency was purely tissue specific (i.e., independent of exposure time) and was unaffected in the heart, reduced in the liver and red and white muscle, and increased in the brain. Downregulation of protein synthesis on a tissue-specific basis appears to be a significant mechanism for energy conservation as well as maintaining neural function, thus promoting survival during anoxia. |
| | |
Authors:
|
R W Smith; D F Houlihan; G E Nilsson; J G Brechin |
Related Documents
:
|
23116199 - Analysis of protein expression profiles in the thymus of chickens infected with marek's... 23495799 - A new generation of carbohydrate-based therapeutics: recombinant mucin-type fusion prot... 8178439 - Specificity of baculovirus p10 functions. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of physiology Volume: 271 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1996 Oct |
Date Detail:
|
Created Date: 1996-12-16 Completed Date: 1996-12-16 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: R897-904 Citation Subset: IM |
Affiliation:
|
Department of Zoology, University of Aberdeen, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anoxia / metabolism* Brain / metabolism Carps / metabolism* Liver / metabolism Muscles / metabolism Myocardium / metabolism Phenylalanine / metabolism Protein Biosynthesis* RNA / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
|
63-91-2/Phenylalanine; 63231-63-0/RNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: AT1 and TxA2/PGH2 receptors maintain hypertension throughout 2K,1C Goldblatt hypertension in the rat...
Next Document: VIP decelerates non-REM-REM cycles and modulates hormone secretion during sleep in men.