Document Detail


Tissue-specific changes in lipid composition and lipoprotein lipase activity during the development of the chick embryo.
MedLine Citation:
PMID:  8418884     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipoprotein lipase was present at a high specific activity in adipose tissue and heart of the chick embryo at the 14th day of development. The enzyme was also present in skeletal muscle but was absent from brain and liver. Major increases in the activity of lipoprotein lipase in adipose tissue and heart occurred from day 12 of development, concomitant with the beginning of the period of lipid uptake from the yolk. These results suggest that lipoprotein lipase may be involved in the utilisation of yolk-derived lipid by the tissues of the embryo. Relatively high levels of docosahexaenoic acid (22:6(n--3)) were present in the triacylglycerol isolated from plasma, adipose tissue, heart and liver. The relative proportions of this fatty acid in the triacylglycerol of the different tissues may be explicable in terms of the substrate specificity of lipoprotein lipase.
Authors:
B K Speake; R C Noble; R J McCartney
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1165     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-02-10     Completed Date:  1993-02-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  263-70     Citation Subset:  IM    
Affiliation:
Department of Biochemical Sciences, Scottish Agricultural College, Auchincruive, Ayr, UK.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / embryology
Animals
Chick Embryo / enzymology,  growth & development*
Docosahexaenoic Acids / analysis
Egg Proteins / metabolism
Heart / embryology
Lipids / analysis*
Lipoprotein Lipase / analysis*
Models, Biological
Sterol O-Acyltransferase / analysis
Substrate Specificity
Triglycerides / chemistry,  isolation & purification
Chemical
Reg. No./Substance:
0/Egg Proteins; 0/Lipids; 0/Triglycerides; 25167-62-8/Docosahexaenoic Acids; EC 2.3.1.26/Sterol O-Acyltransferase; EC 3.1.1.34/Lipoprotein Lipase

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