Document Detail

Tissue-specific and age-related variations in repetitive sequences of mouse extrachromosomal circular DNAs.
MedLine Citation:
PMID:  2320037     Owner:  NLM     Status:  MEDLINE    
Extrachromosomal circular (ecc) DNA was isolated from mouse brain, liver, and heart tissues at different ages. To determine the abundance of repetitive sequences in eccDNAs, preparations were probed for short-interspersed (B1 and B2), long-interspersed (L1), endogenous retroviral-like (IAP), and tandemly repeated satellite sequences (SAT) of the mouse genome. Together these sequence families comprise approximately 15% of the mouse genome. The hybridization results showed that each tissue had a characteristic pattern of repetitive sequence elements in eccDNAs, and the abundance of repetitive sequences changed as a function of age. Repetitive sequences decreased in liver and brain eccDNAs from 1 month to 8 months of age but appeared to remain stable thereafter. In contrast, repetitive sequence families in heart eccDNAs were constant from 1 month to 16 months of age but declined in 24-month-old mice. The present studies indicate that extrachromosomal sequences exhibit greater flexibility than chromosomal sequences.
J W Gaubatz; S C Flores
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  237     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-05-10     Completed Date:  1990-05-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  29-36     Citation Subset:  IM    
Department of Biochemistry, University of South Alabama, College of Medicine, Mobile 36688.
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MeSH Terms
Aging / genetics*
Brain / metabolism
DNA Probes
DNA, Circular / genetics*,  isolation & purification
DNA, Satellite / genetics*,  isolation & purification
Liver / metabolism
Mice, Inbred C57BL
Myocardium / metabolism
Repetitive Sequences, Nucleic Acid / genetics*
Reg. No./Substance:
0/DNA Probes; 0/DNA, Circular; 0/DNA, Satellite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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