| Tissue-specific Cu bioaccumulation patterns and differences in sensitivity to waterborne Cu in three freshwater fish: rainbow trout (Oncorhynchus mykiss), common carp (Cyprinus carpio), and gibel carp (Carassius auratus gibelio). | |
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MedLine Citation:
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PMID: 15550275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rainbow trout (Oncorhynchus mykiss), common carp (Cyprinus carpio) and gibel carp (Carassius auratus gibelio) were exposed to copper (1-20 microM) in softened Antwerp City tap water at pH 7.3 +/- 0.1 and with a water hardness of 292.4 +/- 8.1 mg/L CaCO(3) (Ca 100.8 +/- 3.0 mg/L; Mg 11.0 +/- 0.2 mg/L). LC50s (96 h) were determined and copper accumulation in gills, liver, and kidney assessed over a 10-day period. Rainbow trout (96 h LC50: 3.3 microM/210 microg/L) were three times more sensitive to Cu exposure than common carp (96 h LC50: 10.4 microM/661 microg/L) and almost seven times more sensitive than gibel carp (96 h LC50: 22.0 microM/1398 microg/L). After 96 h, the incipient lethal level (ILL) was reached for common carp, and by the end of the experiment (>120 h) also for rainbow trout. The ILL was never reached for gibel carp. Survival analysis confirmed the differences in sensitivity shown by the 96 h LC50 values. At 1 microM Cu, the relative risk to die was six to seven times greater for rainbow trout as for common or gibel carp, respectively, while it was 9000 and 19,000 times greater at 5 microM Cu. Only the environmental Cu concentrations contributed significantly (P < 0.001) to the Time-To-Death (TTD). Tissue Cu concentrations did not relate to TTD. Among species, a clear difference in metal handling was apparent, with high liver residues and liver accumulation rates for the most sensitive species, the rainbow trout, and lower liver but higher kidney residues and kidney accumulation rates for the most resistant species, the gibel carp. Gill concentrations and accumulation rates were lowest in the sensitive rainbow trout. |
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Authors:
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Gudrun De Boeck; Wouter Meeus; Wim De Coen; Ronny Blust |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Aquatic toxicology (Amsterdam, Netherlands) Volume: 70 ISSN: 0166-445X ISO Abbreviation: Aquat. Toxicol. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-11-19 Completed Date: 2005-02-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8500246 Medline TA: Aquat Toxicol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 179-88 Citation Subset: IM |
Affiliation:
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Ecophysiology, Biochemistry and Toxicology Group, Department of Biology, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium. gudrun.deboeck@ua.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Belgium Body Burden Carps / metabolism* Copper / pharmacokinetics* Fresh Water Gills / metabolism Kidney / metabolism Lethal Dose 50 Liver / metabolism Oncorhynchus mykiss / metabolism* Species Specificity Survival Analysis Time Factors |
| Chemical | |
Reg. No./Substance:
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7440-50-8/Copper |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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