Document Detail

Tissue soldering by use of indocyanine green dye-enhanced fibrinogen with the near infrared diode laser.
MedLine Citation:
PMID:  2335838     Owner:  NLM     Status:  MEDLINE    
Anastomoses welded by laser have been strengthened by applying a solder of fibrinogen combined with a laser energy absorbing dye (indocyanine green, maximum absorbance 805 nm) to the anastomotic site before continuous-wave diode laser exposure (808 +/- 1 nm, 4.8 W/cm2). Immediately after creation, the bursting pressures of welds created without fibrinogen (262 +/- 29 mm Hg, n = 11) were significantly less than repairs with fibrinogen (330 +/- 75 mm Hg, n = 11) (p less than 0.05). When repairs performed with fibrinogen were exposed to urokinase (25,000 IU) the bursting pressures were not significantly different from baseline (290 +/- 74 mm Hg, n = 5). Aortotomies closed by suture did not burst but leaked at pressures significantly below those of vessels closed by laser (165 +/- 9 mm Hg, n = 11) (p less than 0.01). Twenty-two repairs soldered with fibrinogen were incorporated into survival studies in rabbits and examined from 1 to 90 days after operation. No anastomotic ruptures, thromboses, or aneurysms were identified. Soldered sites rapidly regenerated a new intimal surface and healed by myofibroblast proliferation. No significant foreign body response was identified; the fibrinogen was resorbed. Laser soldering with exogenous fibrinogen is feasible without topical administration of additional clotting agents, significantly improves the bursting strength of primary laser welded anastomoses, and appears to result from urokinase-resistant fibrinogen cross-linking.
M C Oz; J P Johnson; S Parangi; R S Chuck; C C Marboe; L S Bass; R Nowygrod; M R Treat
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of vascular surgery     Volume:  11     ISSN:  0741-5214     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-06-11     Completed Date:  1990-06-11     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  718-25     Citation Subset:  IM    
Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY.
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MeSH Terms
Anastomosis, Surgical
Aorta, Abdominal / physiology,  surgery,  ultrastructure
Fibrinogen / therapeutic use*
Indocyanine Green / administration & dosage*
Laser Therapy / methods*
Microscopy, Electron, Scanning
Tissue Survival
Vascular Surgical Procedures / methods*
Grant Support
Reg. No./Substance:
3599-32-4/Indocyanine Green; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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